SHMARQL

Parkin RBR E3 ubiquitin protein ligase

<http://www.wikidata.org/entity/Q14864264>

mammalian protein found in Mus musculus
rdfs:label "Parkin RBR E3 ubiquitin protein ligase"@en
skos:altLabel "E3 ubiquitin-protein ligase parkin"@en
"Park2"@en
"Parkinson disease (autosomal recessive, juvenile) 2, parkin"@en
"Prkn"@en
"parkin RBR E3 ubiquitin-protein ligase"@en
"parkin protein"@en
"uniprot:Q9WVS6"@en
schema:description
"mammalian protein found in Mus musculus"@en
schema:dateModified "2023-12-03T14:50:50+00:00"^^xsd:dateTime
schema:version 2023060825
wikibase:identifiers 19
wikibase:sitelinks 0
wikibase:statements 214
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wd:statement/Q14864264-FC80347E-D6ED-44C4-9656-BBA0CEFAB31A
p:P702 wd:statement/q14864264-42327F86-5962-4696-BB8A-60C09D3155E2
p:P703 wd:statement/q14864264-2B464D0C-BC3E-4F86-A342-5A83182F6B61
p:P705 wd:statement/Q14864264-39971D21-A0F3-4FAD-B237-AD66168C5131
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p:direct-normalized/P352 <http://purl.uniprot.org/uniprot/Q9WVS6>
p:direct-normalized/P637 <http://purl.uniprot.org/refseq/NP_001304655>
<http://purl.uniprot.org/refseq/NP_057903>
<http://purl.uniprot.org/refseq/XP_006523399>
<http://purl.uniprot.org/refseq/XP_006523400>
<http://purl.uniprot.org/refseq/XP_006523402>
<http://purl.uniprot.org/refseq/XP_017173061>
<http://purl.uniprot.org/refseq/XP_017173062>
<http://purl.uniprot.org/refseq/XP_017173063>
<http://purl.uniprot.org/refseq/XP_017173064>
<http://purl.uniprot.org/refseq/XP_017173065>
p:direct-normalized/P638 <https://rdf.wwpdb.org/pdb/1MG8>
<https://rdf.wwpdb.org/pdb/2ZEQ>
<https://rdf.wwpdb.org/pdb/3B1L>
wdt:P31 protein
wdt:P352 "Q9WVS6"
wdt:P361 E3 ubiquitin-protein ligase parkin
Ubiquitin-like domain superfamily
membrane protein
Ubiquitin-like domain, protein family
IBR domain, protein family
wdt:P527 Ubiquitin domain
IBR domain
wdt:P637 "NP_001304655"
"NP_057903"
"XP_006523399"
"XP_006523400"
"XP_006523402"
"XP_017173061"
"XP_017173062"
"XP_017173063"
"XP_017173064"
"XP_017173065"
wdt:P638 "1MG8"
"2ZEQ"
"3B1L"
wdt:P680 metal ion binding
enzyme binding
ubiquitin protein ligase binding
chaperone binding
tubulin binding
identical protein binding
protein kinase binding
G protein-coupled receptor binding
transferase activity
PDZ domain binding
ubiquitin-protein transferase activity
Hsp70 protein binding
phospholipase binding
actin binding
ubiquitin binding
kinase binding
transcription cis-regulatory region binding
histone deacetylase binding
beta-catenin binding
heat shock protein binding
protein binding
ubiquitin protein ligase activity
cullin family protein binding
ubiquitin-specific protease binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
ubiquitin conjugating enzyme binding
F-box domain binding
protein-containing complex binding
wdt:P681 dendrite
endoplasmic reticulum membrane
perinuclear region of cytoplasm
membrane
cell projection
Golgi membrane
neuron projection
soma
nuclear speck
cytoplasmic vesicle
ubiquitin ligase complex
postsynaptic membrane
synaptic vesicle membrane
axon
synapse
cell junction
Parkin-FBXW7-Cul1 ubiquitin ligase complex
LUBAC complex
cytosol
protein-containing complex
presynapse
terminal bouton
intracellular vesicle
mitochondrion-derived vesicle
plasma membrane
intracellular anatomical structure
mitochondrion
nucleus
membrane raft
postsynaptic density
aggresome
synaptic vesicle
cytoplasm
endoplasmic reticulum
Golgi apparatus
wdt:P682 learning
adult locomotory behavior
modulation of chemical synaptic transmission
response to oxidative stress
negative regulation of transcription by RNA polymerase II
regulation of transcription, DNA-templated
positive regulation of gene expression
regulation of apoptotic process
protein stabilization
locomotory behavior
transcription, DNA-templated
positive regulation of apoptotic process
positive regulation of transcription by RNA polymerase II
negative regulation of reactive oxygen species metabolic process
synaptic transmission, dopaminergic
negative regulation of gene expression
positive regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of cell death
negative regulation of neuron apoptotic process
negative regulation of release of cytochrome c from mitochondria
positive regulation of protein binding
negative regulation of canonical Wnt signaling pathway
protein autoubiquitination
negative regulation of protein phosphorylation
protein destabilization
protein K6-linked ubiquitination
dopamine uptake involved in synaptic transmission
dopamine metabolic process
regulation of neurotransmitter secretion
synaptic transmission, glutamatergic
negative regulation of neuron death
protein polyubiquitination
regulation of protein stability
regulation of mitochondrial membrane potential
positive regulation of DNA binding
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of insulin secretion
ubiquitin-dependent protein catabolic process
protein monoubiquitination
regulation of autophagy
negative regulation of actin filament bundle assembly
protein K63-linked ubiquitination
aggresome assembly
protein K48-linked ubiquitination
regulation of reactive oxygen species metabolic process
response to unfolded protein
protein metabolic process
norepinephrine metabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of dopamine metabolic process
response to endoplasmic reticulum stress
negative regulation of excitatory postsynaptic potential
mitochondrion organization
negative regulation of synaptic transmission, glutamatergic
mitochondrial fragmentation involved in apoptotic process
proteasomal protein catabolic process
regulation of protein ubiquitination
positive regulation of mitochondrial membrane potential
negative regulation of JNK cascade
positive regulation of proteasomal protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
mitochondrion localization
autophagy of mitochondrion
positive regulation of mitophagy in response to mitochondrial depolarization
positive regulation of autophagy of mitochondrion
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
regulation of mitochondrion organization
positive regulation of mitochondrial fission
protein K11-linked ubiquitination
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of glucokinase activity
protein localization to mitochondrion
negative regulation by host of viral genome replication
neuron cellular homeostasis
negative regulation of oxidative stress-induced neuron death
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of dendrite extension
positive regulation of ATP biosynthetic process
positive regulation of mitochondrial fusion
cellular response to toxic substance
free ubiquitin chain polymerization
negative regulation of exosomal secretion
negative regulation of mitochondrial fission
negative regulation of mitochondrial fusion
regulation of cellular response to oxidative stress
zinc ion homeostasis
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of spontaneous neurotransmitter secretion
positive regulation of neurotransmitter uptake
negative regulation of primary amine oxidase activity
positive regulation of protein linear polyubiquitination
negative regulation of reactive oxygen species biosynthetic process
mitophagy
cellular response to hydrogen sulfide
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
positive regulation of mitophagy
cellular response to L-glutamate
positive regulation of protein localization to membrane
negative regulation of intralumenal vesicle formation
mitochondrion to lysosome transport
autophagy
protein ubiquitination
regulation of gene expression
startle response
mitochondrial fission
wdt:P702 Prkn
wdt:P703 house mouse
wdt:P705 "ENSMUSP00000127455"
"ENSMUSP00000136268"
"ENSMUSP00000140217"
"ENSMUSP00000140587"
"ENSMUSP00000151830"
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