SHMARQL

BRCA1

<http://www.wikidata.org/entity/Q17487737>

mammalian protein found in Homo sapiens
BRCA1
rdfs:label
"BRCA1"@en
skos:altLabel "BRCA1"@en
"BRCA1 DNA repair associated"@en
"BRCA1 Protein"@en
"BRCA1/BRCA2-containing complex, subunit 1"@en
"Fanconi anemia, complementation group S"@en
"RING finger protein 53"@en
"breast and ovarian cancer susceptibility protein 1"@en
"breast cancer 1, early onset"@en
"breast cancer type 1 susceptibility protein"@en
"early onset breast cancer 1"@en
"protein phosphatase 1, regulatory subunit 53"@en
schema:description
"mammalian protein found in Homo sapiens"@en
schema:dateModified "2026-07-23T15:41:18+00:00"^^xsd:dateTime
schema:version 2521708018
wikibase:identifiers 74
wikibase:sitelinks 27
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p:direct-normalized/P352 <http://purl.uniprot.org/uniprot/P38398>
p:direct-normalized/P486 <http://id.nlm.nih.gov/mesh/D019313>
p:direct-normalized/P637 <http://purl.uniprot.org/refseq/NP_009225>
<http://purl.uniprot.org/refseq/NP_009228>
<http://purl.uniprot.org/refseq/NP_009229>
<http://purl.uniprot.org/refseq/NP_009230>
<http://purl.uniprot.org/refseq/NP_009231>
p:direct-normalized/P638 <https://rdf.wwpdb.org/pdb/1JM7>
<https://rdf.wwpdb.org/pdb/1JNX>
<https://rdf.wwpdb.org/pdb/1N5O>
<https://rdf.wwpdb.org/pdb/1OQA>
<https://rdf.wwpdb.org/pdb/1T15>
<https://rdf.wwpdb.org/pdb/1T29>
<https://rdf.wwpdb.org/pdb/1T2U>
<https://rdf.wwpdb.org/pdb/1T2V>
<https://rdf.wwpdb.org/pdb/1Y98>
<https://rdf.wwpdb.org/pdb/2ING>
<https://rdf.wwpdb.org/pdb/3COJ>
<https://rdf.wwpdb.org/pdb/3K0H>
<https://rdf.wwpdb.org/pdb/3K0K>
<https://rdf.wwpdb.org/pdb/3K15>
<https://rdf.wwpdb.org/pdb/3PXA>
<https://rdf.wwpdb.org/pdb/3PXB>
<https://rdf.wwpdb.org/pdb/3PXC>
<https://rdf.wwpdb.org/pdb/3PXD>
<https://rdf.wwpdb.org/pdb/3PXE>
<https://rdf.wwpdb.org/pdb/4IFI>
<https://rdf.wwpdb.org/pdb/4IGK>
<https://rdf.wwpdb.org/pdb/4JLU>
<https://rdf.wwpdb.org/pdb/4OFB>
<https://rdf.wwpdb.org/pdb/4U4A>
<https://rdf.wwpdb.org/pdb/4Y18>
<https://rdf.wwpdb.org/pdb/4Y2G>
p:direct-normalized/P672 <http://id.nlm.nih.gov/mesh/D12.776.313.125>
<http://id.nlm.nih.gov/mesh/D12.776.624.776.100>
<http://id.nlm.nih.gov/mesh/D12.776.660.100>
<http://id.nlm.nih.gov/mesh/D12.776.744.100>
<http://id.nlm.nih.gov/mesh/D12.776.930.137>
wdt:P13204 "a6c9xju6"
wdt:P18 <http://commons.wikimedia.org/wiki/Special:FilePath/Protein%20BRCA1%20PDB%201jm7.png>
wdt:P2892 "C0259275"
wdt:P31 protein
wdt:P352 "P38398"
wdt:P361 Breast cancer type 1 susceptibility protein (BRCA1)
Zinc finger, RING/FYVE/PHD-type
BRCT domain superfamily
Zinc finger, C3HC4 RING-type, protein family
BRCT domain, protein family
BRCA1, serine-rich domain, protein family
Zinc finger, RING-type, protein family
Zinc finger, RING-type, conserved site, protein family
wdt:P373 "BRCA1"
wdt:P486 "D019313"
wdt:P492 "113705"
wdt:P527 Zinc finger, C3HC4 RING-type
BRCT domain
BRCA1, serine-rich domain
Zinc finger, RING-type, conserved site
Zinc finger, RING-type
wdt:P591 "2.3.2.27"
wdt:P637 "NP_009225"
"NP_009228"
"NP_009229"
"NP_009230"
"NP_009231"
wdt:P638 "1JM7"
"1JNX"
"1N5O"
"1OQA"
"1T15"
"1T29"
"1T2U"
"1T2V"
"1Y98"
"2ING"
"3COJ"
"3K0H"
"3K0K"
"3K15"
"3PXA"
"3PXB"
"3PXC"
"3PXD"
"3PXE"
"4IFI"
"4IGK"
"4JLU"
"4OFB"
"4U4A"
"4Y18"
"4Y2G"
wdt:P646 "/m/0256r1"
wdt:P672 "D12.776.313.125"
"D12.776.624.776.100"
"D12.776.660.100"
"D12.776.744.100"
"D12.776.930.137"
wdt:P680 metal ion binding
RNA binding
enzyme binding
DNA binding
zinc ion binding
ubiquitin protein ligase binding
androgen receptor binding
tubulin binding
identical protein binding
damaged DNA binding
transferase activity
transcription coactivator activity
ubiquitin-protein transferase activity
protein binding
RNA polymerase binding
wdt:P681 nucleoplasm
ubiquitin ligase complex
BRCA1-BARD1 complex
BRCA1-A complex
condensed chromosome
condensed nuclear chromosome
lateral element
protein-containing complex
plasma membrane
chromosome
nucleus
ribonucleoprotein complex
cytoplasm
wdt:P682 DNA replication
apoptotic process
response to estrogen
regulation of transcription, DNA-templated
positive regulation of gene expression
regulation of apoptotic process
negative regulation of transcription, DNA-templated
transcription, DNA-templated
double-strand break repair
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
positive regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
regulation of cell population proliferation
negative regulation of reactive oxygen species metabolic process
regulation of transcription by RNA polymerase II
double-strand break repair via homologous recombination
regulation of transcription by RNA polymerase III
fatty acid biosynthetic process
intrinsic apoptotic signaling pathway in response to DNA damage
response to ionizing radiation
androgen receptor signaling pathway
positive regulation of protein ubiquitination
positive regulation of histone acetylation
negative regulation of fatty acid biosynthetic process
positive regulation of DNA repair
negative regulation of centriole replication
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
protein autoubiquitination
fatty acid metabolic process
positive regulation of histone H4-K20 methylation
cellular response to indole-3-methanol
protein K6-linked ubiquitination
positive regulation of histone H3-K9 acetylation
positive regulation of histone H4-K16 acetylation
DNA recombination
regulation of gene expression by genetic imprinting
dosage compensation by inactivation of X chromosome
negative regulation of histone acetylation
chordate embryonic development
regulation of DNA methylation
negative regulation of histone H3-K4 methylation
positive regulation of histone H3-K9 methylation
protein deubiquitination
transcription by RNA polymerase II
positive regulation of angiogenesis
positive regulation of vascular endothelial growth factor production
cellular response to tumor necrosis factor
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
double-strand break repair via nonhomologous end joining
mitotic G2 DNA damage checkpoint signaling
cell cycle
DNA repair
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of G0 to G1 transition
mitotic G2/M transition checkpoint
regulation of signal transduction by p53 class mediator
DNA double-strand break processing
lipid metabolism
protein ubiquitination
centrosome cycle
chromosome segregation
postreplication repair
wdt:P702 BRCA1
wdt:P703 man
wdt:P705 "ENSP00000312236"
"ENSP00000326002"
"ENSP00000350283"
"ENSP00000397145"
"ENSP00000417148"
"ENSP00000417241"
"ENSP00000417554"
"ENSP00000417988"
"ENSP00000418212"
"ENSP00000418548"
"ENSP00000418775"
"ENSP00000418819"
"ENSP00000418960"
"ENSP00000418986"
"ENSP00000419103"
"ENSP00000419274"
"ENSP00000419481"
"ENSP00000419988"
"ENSP00000420201"
"ENSP00000420253"
"ENSP00000420412"
"ENSP00000420705"
"ENSP00000420781"
"ENSP00000465347"
"ENSP00000465818"
"ENSP00000467329"
"ENSP00000478114"
"ENSP00000489431"
"ENSP00000494614"
"ENSP00000495897"
"ENSP00000496570"
"ENSP00000498906"
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