Mitogen-activated protein kinase kinase 1

mammalian protein found in Homo sapiens
rdfs:label "Mitogen-activated protein kinase kinase 1"@en
skos:altLabel "ERK activator kinase 1"@en
"MAP Kinase Kinase 1"@en
"MAP2K1"@en
"MAPK/ERK kinase 1"@en
"MAPKK 1"@en
"MEK 1"@en
"dual specificity mitogen-activated protein kinase kinase 1"@en
"protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)"@en
schema:description
"mammalian protein found in Homo sapiens"@en
schema:dateModified "2026-07-24T05:40:25+00:00"^^xsd:dateTime
schema:version 2521951613
wikibase:identifiers 52
wikibase:sitelinks 0
wikibase:statements 148
p:P129 wd:statement/Q21100360-1B001E1B-1731-4979-A72F-446A418B5919
wd:statement/Q21100360-2F5F2CDC-990B-4D88-A6CB-D9B3A289BBCE
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wd:statement/Q21100360-600203A4-92D7-418B-A6FC-7AB5DC4FA53E
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wd:statement/Q21100360-9CDDC27C-0952-4B99-9921-29FDA7AD8AA6
wd:statement/Q21100360-C1551C27-5A9A-4129-BF86-70C4F6C24E1D
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wd:statement/Q21100360-E2880B5F-DAE4-433A-B428-39CC4D5883F4
p:P2892 wd:statement/Q21100360-10B88FE6-A6EA-4797-A48E-8E22B238E105
p:P31 wd:statement/Q21100360-AD158639-2134-4780-8D77-351FFF0CED4B
p:P352 wd:statement/Q21100360-6F50E19A-B949-4995-AB32-EC51A8D9092F
p:P361 wd:statement/Q21100360-1EB3FCBB-EFB8-460D-A943-4A2D77B59CA3
wd:statement/Q21100360-65234D0A-89E2-4042-8EB6-C7C3C3C776CD
wd:statement/Q21100360-80499634-D289-4423-B299-08CD29790CA7
wd:statement/Q21100360-CA194DC3-A7E8-4EE9-A018-D99F303BBADA
p:P486 wd:statement/Q21100360-4B6ABB36-CF4D-4780-B8FE-79E2E329DC59
p:P527 wd:statement/Q21100360-14F77972-7CB4-4782-9832-1DF1B730C25C
wd:statement/Q21100360-2ED1EC99-6D70-4734-9DD8-8C5B56D60A81
wd:statement/Q21100360-91CB7C2B-6B69-460D-ABDB-A598A7D9FDD6
p:P591 wd:statement/Q21100360-30458DB4-C951-4982-A204-904893DB28C1
p:P637 wd:statement/Q21100360-4A99B175-2307-47E9-AA36-6A53F46C047E
wd:statement/Q21100360-8B474910-E5E7-41AF-8A1C-ABEDE71C70B8
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wd:statement/Q21100360-DD6DAEC4-D38D-4151-BB6E-61DC9D2241AB
p:P638 wd:statement/Q21100360-0A2585FB-AFBB-4D34-B737-20A067C16836
wd:statement/Q21100360-101E4147-472E-4E5B-9B72-DC6A83C25D48
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wd:statement/Q21100360-AD4BDD28-5903-4765-BAF3-C48749B2EA65
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wd:statement/Q21100360-BACB1B9E-71DA-4DB8-9F7F-1CFE954BBD3A
wd:statement/Q21100360-BDB21D2C-2BEE-4B63-A367-FB056F8A7854
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p:P672 wd:statement/Q21100360-0167cbe7-4717-dcc0-1608-196e2dc9b303
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p:P680 wd:statement/Q21100360-0048073A-D7F2-4E0D-B5E6-975C14CFF9DA
wd:statement/Q21100360-4092E331-A0BB-4951-A024-2D5131764BC0
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wd:statement/Q21100360-CF45A938-0697-4DB9-B1B2-44B8FE0D8D19
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wd:statement/Q21100360-E9B709CE-9554-4C7C-B18C-790D5A846F9F
p:P681 wd:statement/Q21100360-0AA26028-1943-48B3-807B-A2B0A4912056
wd:statement/Q21100360-2CBE1EFC-CEE6-4840-B67A-1D3B75A1044C
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wd:statement/Q21100360-739CB2F4-AA90-409A-809F-7F9845985A93
wd:statement/Q21100360-7F474BFE-8DB5-4B07-9F9E-73E6878A4BAD
wd:statement/Q21100360-9E75C379-C2AE-4129-AB71-3E9B19FEBA8F
wd:statement/Q21100360-B7F68A4D-5E1C-458D-BED5-190E0B38F7DA
wd:statement/Q21100360-D421F919-83E0-4FDC-9C96-AEAF367192D6
wd:statement/Q21100360-E774E5FD-A4D1-42FF-A7DD-EAD4502EA8D3
wd:statement/Q21100360-E93804FD-72E0-4E53-90EA-9352ADE2A713
wd:statement/Q21100360-E9986A1A-8ECD-42FC-957C-50A07CBD22DD
p:P682 wd:statement/Q21100360-0C604F74-4A8D-47F5-97E1-9B85DB896460
wd:statement/Q21100360-0FC62103-5785-461C-AFC2-DC8F32C0AA77
wd:statement/Q21100360-29D0C9BD-1A5E-4A72-A2FA-3CAD728C346D
wd:statement/Q21100360-385B5A63-7E19-4695-8637-3DB49FC9FD72
wd:statement/Q21100360-3E6D75BE-73E6-4B48-9148-B53C05C38ED2
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wd:statement/Q21100360-570180EE-E415-4932-B1A1-5D01974197DF
wd:statement/Q21100360-5AB867B6-C72D-4175-84FD-CA002DC882BD
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wd:statement/Q21100360-78493321-0AB5-401A-8E00-86B9AE89074A
wd:statement/Q21100360-7FA44332-E5E3-4366-BDDB-94F22CD0405E
wd:statement/Q21100360-86614577-87F0-4DE8-B154-3B764079E483
wd:statement/Q21100360-898E0747-F5C8-4D7B-8007-506059A835CC
wd:statement/Q21100360-9073EBE5-3662-453E-9C3E-F430564E79AD
wd:statement/Q21100360-96FA071A-FC30-4EBC-860B-E54CCDEFB97F
wd:statement/Q21100360-9ACFFB19-671C-43F7-A066-36A8274DEFCC
wd:statement/Q21100360-A97FDFCB-BBE7-4FE9-BD14-704A03936AF6
wd:statement/Q21100360-AC74741C-17CE-4CED-BBBE-321EB9C17E5B
wd:statement/Q21100360-AEB4059D-D032-443E-A902-5B253965BC7B
wd:statement/Q21100360-B3F1124A-FB33-4D4A-86F3-9632ECE9BA90
wd:statement/Q21100360-B4B3DA1D-730D-4992-A777-0EE0FDE1EBA0
wd:statement/Q21100360-B6DF39EF-3043-482E-98FB-263E4D2D9013
wd:statement/Q21100360-B7F59267-DB46-4ED6-871A-8C40E75F64F2
wd:statement/Q21100360-B9B3FFF5-BE52-4E5F-BA47-304BCA2001B4
wd:statement/Q21100360-BA75C339-FDBE-402D-BCA1-5145CB5B3C7B
wd:statement/Q21100360-BC8733FB-9B70-4282-B5B3-8DBAD805E27B
wd:statement/Q21100360-BDBAE80F-4E01-417B-83B8-CD57E173CD45
wd:statement/Q21100360-BE228A53-E0D6-456A-8A7D-8EC941210AA0
wd:statement/Q21100360-D2ABA539-0770-4D76-AA12-45A6F3AA8BA3
wd:statement/Q21100360-D3ACE841-8634-4CA1-9A64-EA12F1533573
wd:statement/Q21100360-D8195BC3-41FE-43C9-9826-18B54DAFD847
wd:statement/Q21100360-D90FEFB9-B14B-4F91-AE1A-48A3464CE79E
wd:statement/Q21100360-D992230E-210D-4A57-94AD-4F1BA4C8E1B0
wd:statement/Q21100360-DB1A91F6-950D-4133-8058-E2CBD6111459
wd:statement/Q21100360-DCDC3A2F-6544-4F59-85DE-E4FBBFB9FEA5
wd:statement/Q21100360-EA1F3F12-8917-4D93-8449-29F60A8BC233
wd:statement/Q21100360-EA6FB17E-CFD2-4F02-A077-A0CB638F4A3A
wd:statement/Q21100360-F19D31B0-F659-424B-87C6-AA9B0896B2A5
wd:statement/Q21100360-F7845B31-59A0-4708-9172-7DC14BE28746
wd:statement/Q21100360-F9D67D56-8248-40E2-8720-2FC010C40C78
p:P702 wd:statement/Q21100360-BB342BF7-0EA8-473E-BAA7-E461B7C7B8FD
p:P703 wd:statement/Q21100360-76CAE845-17FD-4CBB-B648-F6453BDCD98B
p:P705 wd:statement/Q21100360-7FEA9E2B-4E30-436D-8585-A1B1A532CA23
wd:statement/Q21100360-8152AE79-8BF9-48E3-9D07-B02495336E48
p:direct-normalized/P352 <http://purl.uniprot.org/uniprot/Q02750>
p:direct-normalized/P486 <http://id.nlm.nih.gov/mesh/D048369>
p:direct-normalized/P637 <http://purl.uniprot.org/refseq/NP_002746>
<http://purl.uniprot.org/refseq/XP_011520085>
<http://purl.uniprot.org/refseq/XP_016877900>
<http://purl.uniprot.org/refseq/XP_016877901>
<http://purl.uniprot.org/refseq/XP_016877902>
p:direct-normalized/P638 <https://rdf.wwpdb.org/pdb/1S9J>
<https://rdf.wwpdb.org/pdb/2P55>
<https://rdf.wwpdb.org/pdb/3DV3>
<https://rdf.wwpdb.org/pdb/3DY7>
<https://rdf.wwpdb.org/pdb/3E8N>
<https://rdf.wwpdb.org/pdb/3EQB>
<https://rdf.wwpdb.org/pdb/3EQC>
<https://rdf.wwpdb.org/pdb/3EQD>
<https://rdf.wwpdb.org/pdb/3EQF>
<https://rdf.wwpdb.org/pdb/3EQG>
<https://rdf.wwpdb.org/pdb/3EQH>
<https://rdf.wwpdb.org/pdb/3EQI>
<https://rdf.wwpdb.org/pdb/3MBL>
<https://rdf.wwpdb.org/pdb/3ORN>
<https://rdf.wwpdb.org/pdb/3OS3>
<https://rdf.wwpdb.org/pdb/3PP1>
<https://rdf.wwpdb.org/pdb/3SLS>
<https://rdf.wwpdb.org/pdb/3V01>
<https://rdf.wwpdb.org/pdb/3V04>
<https://rdf.wwpdb.org/pdb/3VVH>
<https://rdf.wwpdb.org/pdb/3W8Q>
<https://rdf.wwpdb.org/pdb/3WIG>
<https://rdf.wwpdb.org/pdb/3ZLS>
<https://rdf.wwpdb.org/pdb/3ZLW>
<https://rdf.wwpdb.org/pdb/3ZLX>
<https://rdf.wwpdb.org/pdb/3ZLY>
<https://rdf.wwpdb.org/pdb/3ZM4>
<https://rdf.wwpdb.org/pdb/4AN2>
<https://rdf.wwpdb.org/pdb/4AN3>
<https://rdf.wwpdb.org/pdb/4AN9>
<https://rdf.wwpdb.org/pdb/4ANB>
<https://rdf.wwpdb.org/pdb/4ARK>
<https://rdf.wwpdb.org/pdb/4LMN>
<https://rdf.wwpdb.org/pdb/4MNE>
<https://rdf.wwpdb.org/pdb/4U7Z>
<https://rdf.wwpdb.org/pdb/4U80>
<https://rdf.wwpdb.org/pdb/4U81>
<https://rdf.wwpdb.org/pdb/5BX0>
p:direct-normalized/P672 <http://id.nlm.nih.gov/mesh/D08.811.913.696.620.682.700.565.100>
<http://id.nlm.nih.gov/mesh/D08.811.913.696.620.682.725.200.100>
<http://id.nlm.nih.gov/mesh/D12.776.476.563.565.100>
<http://id.nlm.nih.gov/mesh/D12.776.476.568.200.100>
wdt:P129 cobimetinib
binimetinib
azd-8330
ci-1040
E-6201
mirdametinib
pimasertib
selumetinib
trametinib
wdt:P2892 "C0173879"
wdt:P31 protein
wdt:P352 "Q02750"
wdt:P361 Protein kinase-like domain superfamily
Protein kinase domain, protein family
Serine/threonine-protein kinase, active site, protein family
Protein kinase, ATP binding site, protein family
wdt:P486 "D048369"
wdt:P527 protein kinase domain
protein kinase, ATP binding site
serine/threonine-protein kinase, active site
wdt:P591 "2.7.12.2"
wdt:P637 "NP_002746"
"XP_011520085"
"XP_016877900"
"XP_016877901"
"XP_016877902"
wdt:P638 "1S9J"
"2P55"
"3DV3"
"3DY7"
"3E8N"
"3EQB"
"3EQC"
"3EQD"
"3EQF"
"3EQG"
"3EQH"
"3EQI"
"3MBL"
"3ORN"
"3OS3"
"3PP1"
"3SLS"
"3V01"
"3V04"
"3VVH"
"3W8Q"
"3WIG"
"3ZLS"
"3ZLW"
"3ZLX"
"3ZLY"
"3ZM4"
"4AN2"
"4AN3"
"4AN9"
"4ANB"
"4ARK"
"4LMN"
"4MNE"
"4U7Z"
"4U80"
"4U81"
"5BX0"
wdt:P672 "D08.811.913.696.620.682.700.565.100"
"D08.811.913.696.620.682.725.200.100"
"D12.776.476.563.565.100"
"D12.776.476.568.200.100"
wdt:P680 protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
ATP binding
protein N-terminus binding
protein C-terminus binding
protein kinase activity
transferase activity
nucleotide binding
kinase activity
protein tyrosine kinase activity
scaffold protein binding
MAP kinase kinase activity
protein binding
protein serine/threonine kinase activator activity
wdt:P681 membrane
early endosome
late endosome
cytoskeleton
cytosol
plasma membrane
mitochondrion
nucleus
cytoplasm
endoplasmic reticulum
Golgi apparatus
microtubule organizing center
focal adhesion
wdt:P682 peptidyl-tyrosine phosphorylation
negative regulation of cell population proliferation
positive regulation of gene expression
regulation of apoptotic process
MAPK cascade
positive regulation of cell differentiation
positive regulation of transcription, DNA-templated
negative regulation of gene expression
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
regulation of protein phosphorylation
thyroid gland development
thymus development
Bergmann glial cell differentiation
lung morphogenesis
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
peptidyl-threonine phosphorylation
keratinocyte differentiation
cell motility
positive regulation of axonogenesis
neuron differentiation
regulation of mitotic cell cycle
trachea formation
epithelial cell proliferation involved in lung morphogenesis
face development
placenta blood vessel development
regulation of stress-activated MAPK cascade
regulation of Golgi inheritance
regulation of early endosome to late endosome transport
stress-activated protein kinase signaling cascade
regulation of axon regeneration
labyrinthine layer development
cerebellar cortex formation
positive regulation of production of miRNAs involved in gene silencing by miRNA
phosphorylation
development of the heart
chemotaxis
protein phosphorylation
signal transduction
cellular senescence
wdt:P702 MAP2K1
wdt:P703 man
wdt:P705 "ENSP00000302486"
"ENSP00000456438"
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