|
rdfs:label
|
"Mitogen-activated protein kinase kinase 2"@en
|
|
skos:altLabel
|
"ERK activator kinase 2"@en
|
|
"MAP kinase kinase 2"@en
|
|
"MAP2K2"@en
|
|
"MAPK/ERK kinase 2"@en
|
|
"MEK 2"@en
|
|
"dual specificity mitogen-activated protein kinase kinase 2"@en
|
|
"mitogen-activated protein kinase kinase 2, p45"@en
|
|
schema:description
|
"Protein in Homo sapiens"@de
"mammalian protein found in Homo sapiens"@en
"protein"@sv
"protein"@id
"proteinë"@sq
"proteïne in Mitogen-activated protein kinase kinase 2"@nl
"protèin"@ace
"білок людини"@uk
"بروتين في الإنسان العاقل"@ar
|
|
schema:dateModified
|
"2026-07-24T06:23:45+00:00"^^xsd:dateTime
|
|
schema:version
|
2521964045
|
|
wikibase:identifiers
|
17
|
|
wikibase:sitelinks
|
0
|
|
wikibase:statements
|
87
|
|
p:P129
|
wd:statement/Q21116665-1BB82B28-0B5D-4F79-8DD4-A1CB491E7773
|
|
wd:statement/Q21116665-6425A7E9-F185-4162-A4B8-CBCA514047C2
|
|
wd:statement/Q21116665-7E3C9249-0019-4560-B03D-2C5791ABE767
|
|
p:P2892
|
wd:statement/Q21116665-4E1C144B-9DF6-43C0-B76D-8BE047ED2ECF
|
|
p:P31
|
wd:statement/Q21116665-E515D443-9126-438D-A72F-A226B75F6ECA
|
|
p:P352
|
wd:statement/Q21116665-39231C75-2F6D-4E0C-90FB-8651FF41C13C
|
|
p:P361
|
wd:statement/Q21116665-69064117-4DFB-4A8A-B5D4-E2F04B1477C2
|
|
wd:statement/Q21116665-724E40E1-B346-4DD9-AEC6-E9C928BB6FCF
|
|
wd:statement/Q21116665-97755784-396E-44D1-B6E0-67066CED12BE
|
|
wd:statement/Q21116665-F97552FB-F491-4584-B702-5034702A5DD8
|
|
p:P486
|
wd:statement/Q21116665-F23DA8F2-F953-4CAE-B278-E8AB1F1D9BBC
|
|
p:P527
|
wd:statement/Q21116665-475591DF-C782-48AF-8903-001A56D8BF20
|
|
wd:statement/Q21116665-7FE9B604-7982-4A0E-9042-33674792FC97
|
|
wd:statement/Q21116665-A5E9442A-E793-4E8B-9E2C-6F885684FFBA
|
|
p:P591
|
wd:statement/Q21116665-31564F26-B0F5-4825-9612-BE1BC9105F76
|
|
p:P637
|
wd:statement/Q21116665-021DCEAA-09AA-48FE-A4D2-AF2FDFF56A95
|
|
wd:statement/Q21116665-07519B91-6896-43CD-B199-0A8840444AFE
|
|
wd:statement/Q21116665-0E34E0C7-036C-4FFF-B8C4-AE60FE253C1C
|
|
wd:statement/Q21116665-14573FFC-4CD7-45FE-99A9-5D55E5A191C5
|
|
wd:statement/Q21116665-CE743928-AA63-4F5D-8B19-F4F2AF231C3B
|
|
p:P638
|
wd:statement/Q21116665-A3AB81FC-E57E-4AE5-BD2C-E38E7407E7EB
|
|
wd:statement/Q21116665-CFAF5EB0-3CE0-4727-964F-DFD821E48ABE
|
|
p:P672
|
wd:statement/Q21116665-37163fe4-471c-2583-3d25-3599522eee62
|
|
wd:statement/Q21116665-488dcabd-4df3-de6a-7962-d5dc14f29c93
|
|
wd:statement/Q21116665-6b578df7-4c7f-9a27-b519-595925dec14d
|
|
wd:statement/Q21116665-ae70061a-4472-b653-ebfa-b5426caee9bc
|
|
p:P680
|
wd:statement/Q21116665-12FCA799-669A-4D48-B6A1-65B6BC228E57
|
|
wd:statement/Q21116665-2368862E-E0F2-41C4-A389-0CA35FFAB9DA
|
|
wd:statement/Q21116665-2DA69667-B210-40EE-B9CE-51729FF527E4
|
|
wd:statement/Q21116665-4150A9A7-487C-4240-BB0D-4F52578BFD8C
|
|
wd:statement/Q21116665-47A327E7-FC00-40B3-85F5-4864A6EE024C
|
|
wd:statement/Q21116665-6DBFAC49-3445-47E2-9B56-52AE0C71BAC8
|
|
wd:statement/Q21116665-7BAA8CF4-904F-43B9-AAC3-64E9E0A50761
|
|
wd:statement/Q21116665-7C032A32-7511-4960-B48B-23EC1916B1E9
|
|
wd:statement/Q21116665-8F3EE6FB-4680-4674-91E8-6357267ADAEF
|
|
wd:statement/Q21116665-911D2185-2C98-4805-A5C9-968463691178
|
|
wd:statement/Q21116665-A03592EA-5A42-4D8F-ADFB-F7A34F34D104
|
|
wd:statement/Q21116665-AE5802C3-B92B-4B13-829C-2CA492F210B7
|
|
wd:statement/Q21116665-B3BD2E82-04C0-42C0-A3C3-5D0EDFDC1B68
|
|
wd:statement/Q21116665-C3021E66-1868-4013-9E82-3BECB628814C
|
|
wd:statement/Q21116665-F2F2F74E-20D1-43B9-AA72-A0661FA1F911
|
|
wd:statement/Q21116665-FB9BF8D7-7B3D-4FB1-8612-74D0D243E694
|
|
p:P681
|
wd:statement/Q21116665-19F3F903-3033-4386-8E22-C1C0EE52EB17
|
|
wd:statement/Q21116665-1B3C06E3-9817-4528-9449-BF0202289E2D
|
|
wd:statement/Q21116665-1E8D474B-BA53-4B85-AEA0-D20DD7C5F29C
|
|
wd:statement/Q21116665-29B38A89-3277-423A-A5C4-E7F1524DA0FE
|
|
wd:statement/Q21116665-3DD434FE-DEEA-415A-A2F2-5B5BD509FA43
|
|
wd:statement/Q21116665-412CEAFA-7255-4AE8-85C4-A2D49C184BA6
|
|
wd:statement/Q21116665-5A14C88F-F9FA-4A4D-A97C-283067F7046C
|
|
wd:statement/Q21116665-5ABA5BE0-1210-4198-A183-66729E156969
|
|
wd:statement/Q21116665-7732408D-CFDD-4D80-BD76-A57EE1C7627B
|
|
wd:statement/Q21116665-8C1F2676-2158-4048-B918-56E59F293541
|
|
wd:statement/Q21116665-8F305AA0-2421-4D93-9FDA-46F85D15152A
|
|
wd:statement/Q21116665-9B3C78EE-BF23-4D3A-A5B9-D1E410E00F4F
|
|
wd:statement/Q21116665-A29D65D2-9A7F-4A9E-8039-5E6F34BCFBD9
|
|
wd:statement/Q21116665-ACE966FC-4611-4374-8A27-DF8A1D56E06F
|
|
wd:statement/Q21116665-D2403673-795B-46FE-B948-CCB788DE56D2
|
|
wd:statement/Q21116665-DE96C049-009D-4623-B5D3-B38F11F906EC
|
|
wd:statement/Q21116665-E289B6FC-4988-4834-9977-75FDFA31F692
|
|
wd:statement/Q21116665-F2A76F06-232B-4A2B-9587-A18A1D790537
|
|
wd:statement/Q21116665-F37F7603-C260-4D21-8394-8B6422230766
|
|
wd:statement/Q21116665-FC0B1234-6841-4D66-A7E6-B3CA3D7A12BB
|
|
p:P682
|
wd:statement/Q21116665-013320BA-DD80-4FD3-9BAE-465A89E368F3
|
|
wd:statement/Q21116665-068F88E1-6495-428B-B935-F11E1792460B
|
|
wd:statement/Q21116665-07E9C8E0-5798-467E-99EA-A52372610000
|
|
wd:statement/Q21116665-093A244C-FCBC-4A6F-A24D-C300C105DA93
|
|
wd:statement/Q21116665-14F63EC1-8282-4819-80E3-5F8D9F7192A2
|
|
wd:statement/Q21116665-28146D36-5480-4F5E-A8E0-1E79D260052A
|
|
wd:statement/Q21116665-2B9EF0F1-208B-4F99-AE88-7CBDF3FA6A4F
|
|
wd:statement/Q21116665-30A5BC53-6D0F-4D4A-BF65-79E61FD48DCA
|
|
wd:statement/Q21116665-3C99CF53-0C9D-463F-99AD-886A56F61389
|
|
wd:statement/Q21116665-406A9FEF-3889-4411-8A3E-F5078837C808
|
|
wd:statement/Q21116665-755D7321-05CF-450C-95D8-63B989425B65
|
|
wd:statement/Q21116665-7B6EA817-ED33-41B6-86ED-5B5345539E01
|
|
wd:statement/Q21116665-8CBF78A9-B078-4BE2-9AB8-16543C7BCBED
|
|
wd:statement/Q21116665-A20C4E3C-C329-41B7-8D0A-8AF5327B804B
|
|
wd:statement/Q21116665-AABB48F9-42E5-4BA4-B325-115D54B475FA
|
|
wd:statement/Q21116665-C6E7DE1F-A694-4532-B773-261B67750C5D
|
|
wd:statement/Q21116665-D672608C-5F7E-47DE-B8F0-8C9EDF353467
|
|
wd:statement/Q21116665-E6AF6AD3-440F-494F-8F73-DB4E8D0B2DA5
|
|
wd:statement/Q21116665-F22DC188-072D-4D0E-845F-7731484E9A92
|
|
wd:statement/Q21116665-FC784369-D0CE-4D6F-9EC5-939E99AC7CFD
|
|
p:P702
|
wd:statement/Q21116665-9A0EF23C-FFF5-488D-B9A6-D9139B4C2492
|
|
p:P703
|
wd:statement/Q21116665-D482A98F-E48E-4DCD-A374-4DB216711DF4
|
|
p:P705
|
wd:statement/Q21116665-2DC53AB1-056A-4C51-8232-1F5886C8E7E2
|
|
wd:statement/Q21116665-51AD15BB-DE96-40DD-B9B2-D9FE606A76DF
|
|
wd:statement/Q21116665-76F25AA6-B57B-4B4C-A0D6-7625EAB10CE2
|
|
p:direct-normalized/P352
|
<http://purl.uniprot.org/uniprot/P36507>
|
|
p:direct-normalized/P486
|
<http://id.nlm.nih.gov/mesh/D048370>
|
|
p:direct-normalized/P637
|
<http://purl.uniprot.org/refseq/NP_109587>
|
|
<http://purl.uniprot.org/refseq/XP_006722862>
|
|
<http://purl.uniprot.org/refseq/XP_016882478>
|
|
<http://purl.uniprot.org/refseq/XP_016882479>
|
|
<http://purl.uniprot.org/refseq/XP_016882480>
|
|
p:direct-normalized/P638
|
<https://rdf.wwpdb.org/pdb/1S9I>
|
|
<https://rdf.wwpdb.org/pdb/4H3Q>
|
|
p:direct-normalized/P672
|
<http://id.nlm.nih.gov/mesh/D08.811.913.696.620.682.700.565.200>
|
|
<http://id.nlm.nih.gov/mesh/D08.811.913.696.620.682.725.200.200>
|
|
<http://id.nlm.nih.gov/mesh/D12.776.476.563.565.200>
|
|
<http://id.nlm.nih.gov/mesh/D12.776.476.568.200.200>
|
|
wdt:P129
|
cobimetinib
|
|
binimetinib
|
|
trametinib
|
|
wdt:P2892
|
"C0216471"
|
|
wdt:P31
|
protein
|
|
wdt:P352
|
"P36507"
|
|
wdt:P361
|
Protein kinase-like domain superfamily
|
|
Protein kinase domain, protein family
|
|
Serine/threonine-protein kinase, active site, protein family
|
|
Protein kinase, ATP binding site, protein family
|
|
wdt:P486
|
"D048370"
|
|
wdt:P527
|
protein kinase domain
|
|
protein kinase, ATP binding site
|
|
serine/threonine-protein kinase, active site
|
|
wdt:P591
|
"2.7.12.2"
|
|
wdt:P637
|
"NP_109587"
|
|
"XP_006722862"
|
|
"XP_016882478"
|
|
"XP_016882479"
|
|
"XP_016882480"
|
|
wdt:P638
|
"1S9I"
|
|
"4H3Q"
|
|
wdt:P672
|
"D08.811.913.696.620.682.700.565.200"
|
|
"D08.811.913.696.620.682.725.200.200"
|
|
"D12.776.476.563.565.200"
|
|
"D12.776.476.568.200.200"
|
|
wdt:P680
|
metal ion binding
|
|
protein serine/threonine kinase activity
|
|
protein serine/threonine/tyrosine kinase activity
|
|
ATP binding
|
|
protein kinase activity
|
|
transferase activity
|
|
PDZ domain binding
|
|
nucleotide binding
|
|
kinase activity
|
|
protein tyrosine kinase activity
|
|
scaffold protein binding
|
|
MAP kinase kinase activity
|
|
protein binding
|
|
protein serine/threonine kinase activator activity
|
|
wdt:P681
|
perinuclear region of cytoplasm
|
|
membrane
|
|
extracellular region
|
|
peroxisomal membrane
|
|
early endosome
|
|
late endosome
|
|
cell-cell junction
|
|
cytoplasmic side of plasma membrane
|
|
microtubule
|
|
cytosol
|
|
plasma membrane
|
|
mitochondrion
|
|
nucleus
|
|
cytoplasm
|
|
endoplasmic reticulum
|
|
Golgi apparatus
|
|
focal adhesion
|
|
wdt:P682
|
peptidyl-tyrosine phosphorylation
|
|
regulation of apoptotic process
|
|
MAPK cascade
|
|
positive regulation of transcription, DNA-templated
|
|
negative regulation of gene expression
|
|
ERK1 and ERK2 cascade
|
|
positive regulation of ERK1 and ERK2 cascade
|
|
activation of protein kinase activity
|
|
positive regulation of protein serine/threonine kinase activity
|
|
regulation of mitotic cell cycle
|
|
peptidyl-serine autophosphorylation
|
|
regulation of stress-activated MAPK cascade
|
|
regulation of Golgi inheritance
|
|
regulation of early endosome to late endosome transport
|
|
stress-activated protein kinase signaling cascade
|
|
positive regulation of production of miRNAs involved in gene silencing by miRNA
|
|
phosphorylation
|
|
protein phosphorylation
|
|
signal transduction
|
|
wdt:P702
|
MAP2K2
|
|
wdt:P703
|
man
|
|
wdt:P705
|
"ENSP00000262948"
|
|
"ENSP00000378336"
|
|
"ENSP00000471763"
|