SHMARQL

Parkin RBR E3 ubiquitin protein ligase

<http://www.wikidata.org/entity/Q2472777>

mammalian protein found in Homo sapiens
rdfs:label
"Parkin RBR E3 ubiquitin protein ligase"@en
skos:altLabel "E3 ubiquitin-protein ligase parkin"@en
"PARK2"@en
"PRKN"@en
"Parkinson disease (autosomal recessive, juvenile) 2, parkin"@en
"Parkinson disease protein 2"@en
"parkinson juvenile disease protein 2"@en
"parkinson protein 2 E3 ubiquitin protein ligase"@en
"parkinson protein 2, E3 ubiquitin protein ligase (parkin)"@en
schema:description
"mammalian protein found in Homo sapiens"@en
schema:dateModified "2026-09-14T16:59:50+00:00"^^xsd:dateTime
schema:version 2545715108
wikibase:identifiers 31
wikibase:sitelinks 8
wikibase:statements 215
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p:P703 wd:statement/Q2472777-BE654353-C6DE-472B-97F0-8B025A1352AD
p:P705 wd:statement/Q2472777-07193B9A-9B3D-49D3-9131-4C5BA0D16764
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p:direct-normalized/P352 <http://purl.uniprot.org/uniprot/O60260>
p:direct-normalized/P6366 <https://makg.org/entity/2777668072>
p:direct-normalized/P637 <http://purl.uniprot.org/refseq/NP_004553>
<http://purl.uniprot.org/refseq/NP_054642>
<http://purl.uniprot.org/refseq/NP_054643>
<http://purl.uniprot.org/refseq/XP_011534165>
<http://purl.uniprot.org/refseq/XP_016866397>
<http://purl.uniprot.org/refseq/XP_016866398>
<http://purl.uniprot.org/refseq/XP_024302217>
p:direct-normalized/P638 <https://rdf.wwpdb.org/pdb/1IYF>
<https://rdf.wwpdb.org/pdb/2JMO>
<https://rdf.wwpdb.org/pdb/4BM9>
<https://rdf.wwpdb.org/pdb/4I1F>
<https://rdf.wwpdb.org/pdb/4I1H>
<https://rdf.wwpdb.org/pdb/5C1Z>
<https://rdf.wwpdb.org/pdb/5C23>
<https://rdf.wwpdb.org/pdb/5C9V>
wdt:P10283 "C2777668072"
wdt:P2888 <http://purl.uniprot.org/uniprot/O60260>
wdt:P31 protein
wdt:P352 "O60260"
wdt:P361 E3 ubiquitin-protein ligase parkin
Ubiquitin-like domain superfamily
Ubiquitin-like domain, protein family
IBR domain, protein family
wdt:P527 Ubiquitin domain
IBR domain
wdt:P591 "2.3.2.31"
wdt:P6366 "2777668072"
wdt:P637 "NP_004553"
"NP_054642"
"NP_054643"
"XP_011534165"
"XP_016866397"
"XP_016866398"
"XP_024302217"
wdt:P638 "1IYF"
"2JMO"
"4BM9"
"4I1F"
"4I1H"
"5C1Z"
"5C23"
"5C9V"
wdt:P646 "/m/03r3tb"
wdt:P680 metal ion binding
enzyme binding
zinc ion binding
ubiquitin protein ligase binding
chaperone binding
tubulin binding
identical protein binding
DNA-binding transcription factor activity
protein kinase binding
G protein-coupled receptor binding
transferase activity
PDZ domain binding
ubiquitin-protein transferase activity
Hsp70 protein binding
phospholipase binding
actin binding
ubiquitin binding
kinase binding
transcription cis-regulatory region binding
SH3 domain binding
histone deacetylase binding
beta-catenin binding
heat shock protein binding
protein binding
ubiquitin protein ligase activity
cullin family protein binding
ubiquitin-specific protease binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
ubiquitin conjugating enzyme binding
F-box domain binding
protein-containing complex binding
wdt:P681 perinuclear region of cytoplasm
neuron projection
nuclear speck
ubiquitin ligase complex
SCF ubiquitin ligase complex
Lewy body
Parkin-FBXW7-Cul1 ubiquitin ligase complex
LUBAC complex
cytosol
protein-containing complex
presynapse
mitochondrion-derived vesicle
mitochondrion
nucleus
aggresome
cytoplasm
endoplasmic reticulum
Golgi apparatus
wdt:P682 learning
adult locomotory behavior
central nervous system development
modulation of chemical synaptic transmission
response to oxidative stress
negative regulation of transcription by RNA polymerase II
regulation of transcription, DNA-templated
positive regulation of gene expression
regulation of apoptotic process
protein stabilization
locomotory behavior
transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of reactive oxygen species metabolic process
synaptic transmission, dopaminergic
negative regulation of gene expression
negative regulation of cell death
negative regulation of neuron apoptotic process
negative regulation of release of cytochrome c from mitochondria
positive regulation of protein binding
negative regulation of canonical Wnt signaling pathway
protein autoubiquitination
negative regulation of protein phosphorylation
regulation of dopamine secretion
protein destabilization
protein K6-linked ubiquitination
dopamine uptake involved in synaptic transmission
dopamine metabolic process
regulation of neurotransmitter secretion
synaptic transmission, glutamatergic
negative regulation of neuron death
protein polyubiquitination
regulation of protein stability
regulation of mitochondrial membrane potential
positive regulation of DNA binding
regulation of glucose metabolic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of insulin secretion
ubiquitin-dependent protein catabolic process
protein deubiquitination
protein monoubiquitination
regulation of autophagy
negative regulation of actin filament bundle assembly
protein K63-linked ubiquitination
aggresome assembly
protein K48-linked ubiquitination
regulation of reactive oxygen species metabolic process
protein metabolic process
norepinephrine metabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein catabolic process
regulation of dopamine metabolic process
response to endoplasmic reticulum stress
mitochondrion organization
regulation of lipid transport
macroautophagy
proteasomal protein catabolic process
regulation of protein ubiquitination
regulation of canonical Wnt signaling pathway
negative regulation of JNK cascade
positive regulation of proteasomal protein catabolic process
cellular response to manganese ion
proteasome-mediated ubiquitin-dependent protein catabolic process
autophagy of mitochondrion
positive regulation of mitophagy in response to mitochondrial depolarization
positive regulation of autophagy of mitochondrion
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of oxidative stress-induced cell death
protein K27-linked ubiquitination
regulation of mitochondrion organization
positive regulation of mitochondrial fission
protein K11-linked ubiquitination
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of glucokinase activity
ERAD pathway
protein localization to mitochondrion
negative regulation by host of viral genome replication
neuron cellular homeostasis
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of dendrite extension
regulation of protein targeting to mitochondrion
positive regulation of mitochondrial fusion
cellular response to dopamine
cellular response to toxic substance
regulation of synaptic vesicle transport
protein K29-linked ubiquitination
free ubiquitin chain polymerization
negative regulation of exosomal secretion
negative regulation of mitochondrial fusion
regulation of cellular response to oxidative stress
Unfolded protein response
zinc ion homeostasis
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of spontaneous neurotransmitter secretion
positive regulation of neurotransmitter uptake
negative regulation of primary amine oxidase activity
positive regulation of protein linear polyubiquitination
mitophagy
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
positive regulation of retrograde transport, endosome to Golgi
positive regulation of protein localization to membrane
negative regulation of intralumenal vesicle formation
mitochondrion to lysosome transport
autophagy
protein ubiquitination
startle response
mitochondrial fission
wdt:P692 <http://commons.wikimedia.org/wiki/Special:FilePath/PBB%20GE%20PARK2%20207058%20s%20at%20fs.png>
wdt:P702 PRKN
wdt:P703 man
wdt:P705 "ENSP00000343589"
"ENSP00000355858"
"ENSP00000355860"
"ENSP00000355862"
"ENSP00000355863"
"ENSP00000355865"
"ENSP00000434414"
"ENSP00000478353"
"ENSP00000480716"
"ENSP00000483773"
"ENSP00000484112"
"ENSP00000501207"
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