SHMARQL

sirolimus

<http://www.wikidata.org/entity/Q32089>

Immunosuppressive medicine used to prevent rejection of transplanted organs
rdfs:label
"sirolimus"@en
skos:altLabel
"(-)-rapamycin"@en
"AY-22989"@en
"WY-090217"@en
"rapamycin"@en
schema:description
"Immunosuppressive medicine used to prevent rejection of transplanted organs"@en
schema:dateModified "2026-11-04T13:42:52+00:00"^^xsd:dateTime
schema:version 2564708407
wikibase:identifiers 51
wikibase:sitelinks 32
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p:P9272 wd:statement/Q32089-F30C64AB-4534-4532-A970-5803EF713544
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p:direct-normalized/P2115 <http://purl.bioontology.org/ontology/NDFRT/N0000148624>
p:direct-normalized/P244 <http://id.loc.gov/authorities/names/sh2001005861>
p:direct-normalized/P486 <http://id.nlm.nih.gov/mesh/D020123>
p:direct-normalized/P592 <http://rdf.ebi.ac.uk/resource/chembl/molecule/CHEMBL413>
p:direct-normalized/P6366 <https://makg.org/entity/2777921159>
p:direct-normalized/P661 <http://rdf.chemspider.com/10482078>
p:direct-normalized/P662 <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5284616>
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wdt:P10283 "C2777921159"
wdt:P11089 "123924"
wdt:P11143 "Sirolimus"
wdt:P11198 "2446"
wdt:P11199 "PD003301"
wdt:P117 <http://commons.wikimedia.org/wiki/Special:FilePath/Sirolimus.svg>
wdt:P129 FKBP prolyl isomerase 1A
wdt:P13204 "muudk6xc"
wdt:P13591 "concept/d39adf49-2a29-472d-bec6-ce4fadd58fca"
wdt:P1417 "science/rapamycin"
wdt:P1748 "C1212"
wdt:P2017 "CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC)CC[C@H]1O"
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wdt:P2067 913.555142^^xsd:decimal
wdt:P2085 "J137.896A"
wdt:P2115 "N0000148624"
wdt:P2167 "51201515"
wdt:P2175 renal cell carcinoma
graft-versus-host disease
transplant rejection
lymphangioleiomyomatosis
pachyonychia congenita
wdt:P2275
"sirolimus"@en
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wdt:P232 "610-965-5"
wdt:P233 "CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC"
wdt:P234 "InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1"
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wdt:P2566 "100.107.147"
wdt:P267 "L04AA10"
"S01XA23"
wdt:P274 "C₅₁H₇₉NO₁₃"
wdt:P279 (32RS)-rapamycin
alkaloid
wdt:P2840 "226080"
"758664"
wdt:P2849 Streptomyces rapamycinicus
wdt:P2868 antibiotic
immunosuppressive drug
antineoplastic antibiotics
antifungal
protein kinase inhibitors
bactericide
wdt:P2877 "3463"
wdt:P31 type of chemical entity
wdt:P3117 "DTXSID5023582"
wdt:P3222 "rapamycin"
"sirolimus"
wdt:P3345 "35302"
wdt:P3350 "7104"
wdt:P3364 LSM-4886
LSM-6188
wdt:P3489 US pregnancy category C
Australian pregnancy category C
wdt:P3493 boxed warning
wdt:P361 cellular response to rapamycin
response to rapamycin
wdt:P3636 "RAP"
wdt:P366 medication
chemical probe
biological research
wdt:P373 "Sirolimus"
wdt:P3776 mechanistic target of rapamycin kinase
wdt:P3780 Rapamune
wdt:P4235 "sirolimus"
wdt:P4250 3.0^^xsd:decimal
wdt:P486 "D020123"
wdt:P527 hydrogen
carbon
nitrogen
oxygen
wdt:P592 "CHEMBL413"
wdt:P595 "6031"
wdt:P636 intraperitoneal injection
oral administration
intravenous infusion and defusion
wdt:P6366 "2777921159"
wdt:P646 "/m/02m01g"
wdt:P652 "W36ZG6FT64"
wdt:P661 "10482078"
wdt:P662 "5284616"
wdt:P665 "C07909"
wdt:P672 "D02.540.505.760"
wdt:P683 "9168"
wdt:P703 Ophiocordyceps
Streptomyces iranensis
Streptomyces rapamycinicus
Streptomyces hygroscopicus
Purpureocillium
wdt:P715 "DB00877"
wdt:P769 erythromycin
cyclosporine
ketoconazole
itraconazole
fluconazole
diltiazem
ritonavir
wdt:P7746 "NPA000414"
wdt:P7783 "200907050996917166"
wdt:P8189 "987007542160305171"
wdt:P8224 <http://commons.wikimedia.org/wiki/Special:FilePath/Sirolimus3d.png>
wdt:P8494 "DTXCID503582"
wdt:P9272 "33809"
wdt:P973 <https://pmc.ncbi.nlm.nih.gov/articles/PMC12226543/>
<https://www.medchemexpress.com/gb/en/Rapamycin.html>
<https://www.newscientist.com/article/2516893-rapamycin-can-add-years-to-your-life-or-none-at-all-its-a-lottery>
<https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext>
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