SHMARQL

linaclotide

<http://www.wikidata.org/entity/Q3832559>

chemical compound
rdfs:label
"linaclotide"@en
skos:altLabel
"Cys cys glu tyr cys cys asn pro ala cys thr gly cys tyr (disulfide bridge: 1-6; 2-10; 5-13)"@en
"L-Cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine cyclic (1->6),(2->10),(5->13)-tris(disulfide)"@en
"Linaclotide"@en
"Linzess"@en
schema:description
"chemical compound"@en
schema:dateModified "2026-11-04T08:53:06+00:00"^^xsd:dateTime
schema:version 2564625525
wikibase:identifiers 31
wikibase:sitelinks 15
wikibase:statements 53
p:P10245 wd:statement/Q3832559-ab45896a-4767-3c63-30d3-94480b769b06
p:P11089 wd:statement/Q3832559-810FD36D-5328-4DC0-B431-2500D3DE3B42
p:P11143 wd:statement/Q3832559-F1CFAD28-E250-463B-AB2B-F7809A30CBF8
p:P11198 wd:statement/Q3832559-41D0A802-DB79-48B9-8442-FFEAB5DB963A
p:P11199 wd:statement/Q3832559-EF3A1A2F-80DF-46F6-A8F2-1B96B80AE03D
p:P117 wd:statement/Q3832559-e6ee37c5-4a7d-884b-b608-2f4bd661a5d9
p:P129 wd:statement/Q3832559-AC5EB8B4-73D0-4C04-9310-815B4C972699
p:P2017 wd:statement/Q3832559-667C85B4-7D93-4B1F-A99C-493559F5E89E
p:P2062 wd:statement/Q3832559-BDC2F503-45BE-496D-8C07-1B501AC8ABFD
p:P2067 wd:statement/Q3832559-230ECFF1-904B-442F-9D02-F1B06C1AAB1E
p:P2115 wd:statement/Q3832559-C424F542-8A78-42FE-BA37-66928092D031
p:P2175 wd:statement/Q3832559-20E3EB20-B86D-4224-A62A-C929656320A8
wd:statement/Q3832559-7CB6342C-6F5A-4FDF-ACA8-C23C0279F05C
wd:statement/Q3832559-870EABA2-8AD8-4FFD-B790-EE5B636D747B
wd:statement/Q3832559-F6B91811-D2E7-4D95-B805-56A503A7251C
p:P231 wd:statement/Q3832559-EBDB6A93-DC99-46BF-B4A0-FE32842BD306
p:P232 wd:statement/Q3832559-DC8BED3C-F6E4-494B-88CC-7BB7C8F48ABD
p:P233 wd:statement/Q3832559-304AEBF3-3201-4E74-B069-69700A472919
p:P234 wd:statement/Q3832559-9C47C434-35E1-40A0-9F9E-6FA2CEEBEF69
p:P235 wd:statement/Q3832559-FC613BE5-73F0-4ABD-9F49-276E7309C738
p:P2566 wd:statement/Q3832559-4F8C026A-383B-4770-A644-ED79949221C3
p:P267 wd:statement/Q3832559-7DFED20B-3B3D-4FC5-9392-EB6FD8CF3047
p:P274 wd:statement/Q3832559-4B6B5191-1DBD-4CE9-BAB7-A13445674F2D
p:P279 wd:statement/Q3832559-804455AF-1366-4B5F-8B6C-F06098FFFCA5
p:P2868 wd:statement/Q3832559-491916D8-CE53-4F2D-8E04-3BA4D2EEB730
p:P2877 wd:statement/Q3832559-93E56D9F-44AA-480C-83AD-FD86D94DE1F9
p:P2892 wd:statement/Q3832559-DE97A70C-E354-4ED6-8A94-5A462C07366C
p:P31 wd:statement/Q3832559-77815544-67F1-42E7-A114-C976B8E40EF7
p:P3117 wd:statement/Q3832559-75D068A2-CD73-40FC-8A34-3E47449E5559
p:P3345 wd:statement/Q3832559-841AA698-F399-41E5-8F33-BA8110957538
p:P3489 wd:statement/Q3832559-06446B16-40E9-489E-BB25-CBDBBBECECE7
p:P3493 wd:statement/Q3832559-17D95EC4-50AE-49C3-836B-91960852DEDC
p:P366 wd:statement/Q3832559-3F1F3AC2-06F0-40D5-8ECB-23F258F00A3B
p:P373 wd:statement/Q3832559-ed2cd75e-45f1-276b-25ac-5b70b8d9d404
p:P3780 wd:statement/Q3832559-55ABBB7C-A22F-4CD0-997B-AA3BA7A37254
wd:statement/Q3832559-5E3482EA-E7DE-4990-A012-698BA041816D
p:P4235 wd:statement/Q3832559-2AB6AFDD-E082-4108-A55F-ACEBA7D2A705
p:P4250 wd:statement/Q3832559-1E341499-421D-44CC-82C1-96E864572D51
p:P486 wd:statement/Q3832559-A5C8B72F-B12E-4D82-A70B-117D2170832D
p:P592 wd:statement/Q3832559-D77AE39A-C34F-4937-BE12-999A2B9C1518
p:P595 wd:statement/Q3832559-2007105b-4a40-d956-adef-5bf92cae8641
p:P6366 wd:statement/Q3832559-B4357BC5-B297-4851-B226-BE777ECAD9DF
p:P646 wd:statement/Q3832559-B181DD1E-402B-4973-940B-8F98DD3047E2
p:P652 wd:statement/Q3832559-5FC7C57F-944E-441B-99AA-EEEB8EF1230D
p:P661 wd:statement/Q3832559-2141A787-E594-4933-820D-FC4D029B9492
p:P662 wd:statement/Q3832559-B7BA36C8-59A6-410F-B2D7-B9C925A61F13
p:P665 wd:statement/Q3832559-130FC17F-2967-427C-83D1-CCCD7B30883C
p:P683 wd:statement/Q3832559-6B895503-2F01-49C3-816C-CCB706AD20F3
p:P703 wd:statement/Q3832559-FCAB4042-1CCF-41C7-9573-18502CE55220
p:P715 wd:statement/Q3832559-61EDA10F-A47C-4ECF-9C49-5AE0496634BC
p:P7830 wd:statement/Q3832559-6C68764A-913B-4926-8843-8E3606B4F5D0
p:P8026 wd:statement/Q3832559-07078066-6A74-4AB2-B606-140A9FD195FD
p:P8494 wd:statement/Q3832559-342198D7-4CAE-4F09-B800-C4F13E39A655
p:direct-normalized/P2115 <http://purl.bioontology.org/ontology/NDFRT/N0000186137>
p:direct-normalized/P486 <http://id.nlm.nih.gov/mesh/C523483>
p:direct-normalized/P592 <http://rdf.ebi.ac.uk/resource/chembl/molecule/CHEMBL3301675>
p:direct-normalized/P6366 <https://makg.org/entity/2780829607>
p:direct-normalized/P661 <http://rdf.chemspider.com/17314504>
p:direct-normalized/P662 <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID16158208>
p:direct-normalized/P665 <http://www.kegg.jp/entry/D09355>
p:direct-normalized/P683 <http://purl.obolibrary.org/obo/CHEBI_68551>
wdt:P10245 "a613007"
wdt:P11089 "27266355"
wdt:P11143 "Linaclotide"
wdt:P11198 "4622"
wdt:P11199 "PD001153"
wdt:P117 <http://commons.wikimedia.org/wiki/Special:FilePath/Linaclotide%20structure.svg>
wdt:P129 Guanylate cyclase 2C
wdt:P2017 "C[C@H]1C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)O)C(=O)N[C@@H](CSSC[C@@H](C(=O)N3)N)C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N1)CC(=O)N)CC6=CC=C(C=C6)O)CCC(=O)O"
wdt:P2062 "8224"
wdt:P2067 1525.39^^xsd:decimal
wdt:P2115 "N0000186137"
wdt:P2175 constipation
irritable bowel syndrome
wdt:P231 "851199-59-2"
wdt:P232 "812-291-9"
wdt:P233 "CC1C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)CNC(=O)C(NC2=O)C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)O)C(=O)NC(CSSCC(C(=O)N3)N)C(=O)NC(C(=O)N5CCCC5C(=O)N1)CC(=O)N)CC6=CC=C(C=C6)O)CCC(=O)O"
wdt:P234 "InChI=1S/C59H79N15O21S6/c1-26-47(82)69-41-25-101-99-22-38-52(87)65-33(13-14-45(80)81)49(84)66-34(16-28-5-9-30(76)10-6-28)50(85)71-40(54(89)72-39(23-97-96-20-32(60)48(83)70-38)53(88)67-35(18-43(61)78)58(93)74-15-3-4-42(74)56(91)63-26)24-100-98-21-37(64-44(79)19-62-57(92)46(27(2)75)73-55(41)90)51(86)68-36(59(94)95)17-29-7-11-31(77)12-8-29/h5-12,26-27,32-42,46,75-77H,3-4,13-25,60H2,1-2H3,(H2,61,78)(H,62,92)(H,63,91)(H,64,79)(H,65,87)(H,66,84)(H,67,88)(H,68,86)(H,69,82)(H,70,83)(H,71,85)(H,72,89)(H,73,90)(H,80,81)(H,94,95)/t26-,27+,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1"
wdt:P235 "KXGCNMMJRFDFNR-WDRJZQOASA-N"
wdt:P2566 "100.243.239"
wdt:P267 "A06AX04"
wdt:P274 "C₅₉H₇₉N₁₅O₂₁S₆"
wdt:P279 biogenic cyclopeptide
wdt:P2868 guanylyl cyclase C agonist
wdt:P2877 "13114620"
wdt:P2892 "C2000261"
wdt:P31 type of chemical entity
wdt:P3117 "DTXSID90234256"
wdt:P3345 "1307404"
wdt:P3489 US pregnancy category C
wdt:P3493 boxed warning
wdt:P366 medication
wdt:P373 "Linaclotide"
wdt:P3780 Constella
Linzess
wdt:P4235 "linaclotide"
wdt:P4250 0.29^^xsd:decimal
wdt:P486 "C523483"
wdt:P592 "CHEMBL3301675"
wdt:P595 "5017"
wdt:P6366 "2780829607"
wdt:P646 "/m/0dd8vmm"
wdt:P661 "17314504"
wdt:P662 "16158208"
wdt:P665 "D09355"
wdt:P683 "68551"
wdt:P703 Escherichia coli
wdt:P715 "DB08890"
wdt:P7830 "Linaclotide"
wdt:P8026 LiverTox toxicity likelihood category E
wdt:P8494 "DTXCID90156747"
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data from SPARQL profile: Wikidata