SHMARQL

Coagulation factor II, thrombin

<http://www.wikidata.org/entity/Q409166>

mammalian protein found in Homo sapiens
rdfs:label
"Coagulation factor II, thrombin"@en
skos:altLabel
"Coagulation factor II"@en
"F2"@en
"prepro-coagulation factor II"@en
"prothrombin"@en
"prothrombin B-chain"@en
"serine protease"@en
"thrombin"@en
"thrombin factor II"@en
schema:description
"mammalian protein found in Homo sapiens"@en
schema:dateModified "2026-11-04T14:21:24+00:00"^^xsd:dateTime
schema:version 2564718562
wikibase:identifiers 411
wikibase:sitelinks 37
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<https://rdf.wwpdb.org/pdb/3RML>
<https://rdf.wwpdb.org/pdb/3RMM>
<https://rdf.wwpdb.org/pdb/3RMN>
<https://rdf.wwpdb.org/pdb/3RMO>
<https://rdf.wwpdb.org/pdb/3S7H>
<https://rdf.wwpdb.org/pdb/3S7K>
<https://rdf.wwpdb.org/pdb/3SHA>
<https://rdf.wwpdb.org/pdb/3SHC>
<https://rdf.wwpdb.org/pdb/3SI3>
<https://rdf.wwpdb.org/pdb/3SI4>
<https://rdf.wwpdb.org/pdb/3SQE>
<https://rdf.wwpdb.org/pdb/3SQH>
<https://rdf.wwpdb.org/pdb/3SV2>
<https://rdf.wwpdb.org/pdb/3T5F>
<https://rdf.wwpdb.org/pdb/3TU7>
<https://rdf.wwpdb.org/pdb/3U69>
<https://rdf.wwpdb.org/pdb/3U8O>
<https://rdf.wwpdb.org/pdb/3U8R>
<https://rdf.wwpdb.org/pdb/3U8T>
<https://rdf.wwpdb.org/pdb/3U98>
<https://rdf.wwpdb.org/pdb/3U9A>
<https://rdf.wwpdb.org/pdb/3UTU>
<https://rdf.wwpdb.org/pdb/3UWJ>
<https://rdf.wwpdb.org/pdb/3VXE>
<https://rdf.wwpdb.org/pdb/3VXF>
<https://rdf.wwpdb.org/pdb/4AX9>
<https://rdf.wwpdb.org/pdb/4AYV>
<https://rdf.wwpdb.org/pdb/4AYY>
<https://rdf.wwpdb.org/pdb/4AZ2>
<https://rdf.wwpdb.org/pdb/4BAH>
<https://rdf.wwpdb.org/pdb/4BAK>
<https://rdf.wwpdb.org/pdb/4BAM>
<https://rdf.wwpdb.org/pdb/4BAN>
<https://rdf.wwpdb.org/pdb/4BAO>
<https://rdf.wwpdb.org/pdb/4BAQ>
<https://rdf.wwpdb.org/pdb/4BOH>
<https://rdf.wwpdb.org/pdb/4CH2>
<https://rdf.wwpdb.org/pdb/4CH8>
<https://rdf.wwpdb.org/pdb/4DIH>
<https://rdf.wwpdb.org/pdb/4DII>
<https://rdf.wwpdb.org/pdb/4DT7>
<https://rdf.wwpdb.org/pdb/4DY7>
<https://rdf.wwpdb.org/pdb/4E05>
<https://rdf.wwpdb.org/pdb/4E06>
<https://rdf.wwpdb.org/pdb/4E7R>
<https://rdf.wwpdb.org/pdb/4H6S>
<https://rdf.wwpdb.org/pdb/4H6T>
<https://rdf.wwpdb.org/pdb/4HFP>
<https://rdf.wwpdb.org/pdb/4HTC>
<https://rdf.wwpdb.org/pdb/4HZH>
<https://rdf.wwpdb.org/pdb/4I7Y>
<https://rdf.wwpdb.org/pdb/4LOY>
<https://rdf.wwpdb.org/pdb/4LXB>
<https://rdf.wwpdb.org/pdb/4LZ1>
<https://rdf.wwpdb.org/pdb/4LZ4>
<https://rdf.wwpdb.org/pdb/4MLF>
<https://rdf.wwpdb.org/pdb/4N3L>
<https://rdf.wwpdb.org/pdb/4NZE>
<https://rdf.wwpdb.org/pdb/4NZQ>
<https://rdf.wwpdb.org/pdb/4O03>
<https://rdf.wwpdb.org/pdb/4RKJ>
<https://rdf.wwpdb.org/pdb/4RKO>
<https://rdf.wwpdb.org/pdb/4RN6>
<https://rdf.wwpdb.org/pdb/4THN>
<https://rdf.wwpdb.org/pdb/4UD9>
<https://rdf.wwpdb.org/pdb/4UDW>
<https://rdf.wwpdb.org/pdb/4UE7>
<https://rdf.wwpdb.org/pdb/4UEH>
<https://rdf.wwpdb.org/pdb/4UFD>
<https://rdf.wwpdb.org/pdb/4UFE>
<https://rdf.wwpdb.org/pdb/4UFF>
<https://rdf.wwpdb.org/pdb/4UFG>
<https://rdf.wwpdb.org/pdb/4YES>
<https://rdf.wwpdb.org/pdb/5A2M>
<https://rdf.wwpdb.org/pdb/5AF9>
<https://rdf.wwpdb.org/pdb/5AFY>
<https://rdf.wwpdb.org/pdb/5AFZ>
<https://rdf.wwpdb.org/pdb/5AHG>
<https://rdf.wwpdb.org/pdb/5CMX>
<https://rdf.wwpdb.org/pdb/5E8E>
<https://rdf.wwpdb.org/pdb/5EDK>
<https://rdf.wwpdb.org/pdb/5EDM>
<https://rdf.wwpdb.org/pdb/5GDS>
<https://rdf.wwpdb.org/pdb/5JDU>
<https://rdf.wwpdb.org/pdb/7KME>
<https://rdf.wwpdb.org/pdb/8KME>
p:direct-normalized/P672 <http://id.nlm.nih.gov/mesh/D08.811.277.656.300.760.855>
<http://id.nlm.nih.gov/mesh/D08.811.277.656.959.350.855>
<http://id.nlm.nih.gov/mesh/D12.776.124.125.890>
<http://id.nlm.nih.gov/mesh/D23.119.960>
p:direct-normalized/P8408 <http://kbpedia.org/kko/rc/SerineProtease>
p:direct-normalized/P8814 <http://wordnet-rdf.princeton.edu/rdf/id/14761428-n>
wdt:P10283 "C2777292125"
"C3018972837"
wdt:P1036 "612.115"
wdt:P12385 "trombina"
wdt:P129 dabigatran etexilate
argatroban
ximelagatran
dabigatran
wdt:P1296 "0148507"
wdt:P1343 Armenian Soviet Encyclopedia
wdt:P13591 "concept/44c33fcd-426c-4ca3-b0ca-bb2c73d1084e"
wdt:P2004 "18114"
wdt:P2347 "20710"
wdt:P244 "sh85135066"
wdt:P267 "B02BC06"
"B02BD30"
wdt:P2671 "/g/1222ck19"
wdt:P268 "12316045k"
wdt:P2888 <http://purl.uniprot.org/uniprot/P00734>
wdt:P2924 "4205018"
wdt:P31 protein
wdt:P3365 "trombina"
wdt:P3471 "15414"
"15523"
wdt:P352 "P00734"
wdt:P361 prothrombin/thrombin
Kringle-like fold
Peptidase S1, PA clan
Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Thrombin light chain domain superfamily
Kringle superfamily
Kringle domain, protein family
Gamma-carboxyglutamic acid-rich (GLA) domain, protein family
Serine proteases, trypsin domain, protein family
Thrombin light chain, protein family
Kringle, conserved site, protein family
Serine proteases, trypsin family, serine active site, protein family
Serine proteases, trypsin family, histidine active site, protein family
wdt:P373 "Thrombin"
wdt:P486 "D013917"
wdt:P508 "1272"
wdt:P527 kringle, conserved site
Serine proteases, trypsin family, serine active site
serine proteases, trypsin family, histidine active site
kringle
gamma-carboxyglutamic acid-rich (GLA) domain
serine proteases, trypsin domain
thrombin light chain
wdt:P591 "3.4.21.5"
wdt:P6366 "2777292125"
"2908619273"
"2909996470"
"2910227443"
wdt:P637 "NP_000497"
wdt:P638 "1A2C"
"1A3B"
"1A3E"
"1A46"
"1A4W"
"1A5G"
"1A61"
"1ABI"
"1ABJ"
"1AD8"
"1AE8"
"1AFE"
"1AHT"
"1AI8"
"1AIX"
"1AWF"
"1AWH"
"1AY6"
"1B5G"
"1B7X"
"1BA8"
"1BB0"
"1BCU"
"1BHX"
"1BMM"
"1BMN"
"1BTH"
"1C1U"
"1C1V"
"1C1W"
"1C4U"
"1C4V"
"1C4Y"
"1C5L"
"1C5N"
"1C5O"
"1CA8"
"1D3D"
"1D3P"
"1D3Q"
"1D3T"
"1D4P"
"1D6W"
"1D9I"
"1DE7"
"1DIT"
"1DM4"
"1DOJ"
"1DWB"
"1DWC"
"1DWD"
"1DWE"
"1DX5"
"1E0F"
"1EB1"
"1EOJ"
"1EOL"
"1FPC"
"1FPH"
"1G30"
"1G32"
"1G37"
"1GHV"
"1GHW"
"1GHX"
"1GHY"
"1GJ4"
"1GJ5"
"1H8D"
"1H8I"
"1HAG"
"1HAH"
"1HAI"
"1HAO"
"1HAP"
"1HBT"
"1HDT"
"1HGT"
"1HLT"
"1HUT"
"1HXE"
"1HXF"
"1IHS"
"1IHT"
"1JMO"
"1JOU"
"1JWT"
"1K21"
"1K22"
"1KTS"
"1KTT"
"1LHC"
"1LHD"
"1LHE"
"1LHF"
"1LHG"
"1MH0"
"1MU6"
"1MU8"
"1MUE"
"1NM6"
"1NO9"
"1NRN"
"1NRO"
"1NRP"
"1NRQ"
"1NRR"
"1NRS"
"1NT1"
"1NU7"
"1NU9"
"1NY2"
"1NZQ"
"1O0D"
"1O2G"
"1O5G"
"1OOK"
"1OYT"
"1P8V"
"1PPB"
"1QBV"
"1QHR"
"1QJ1"
"1QJ6"
"1QJ7"
"1QUR"
"1RD3"
"1RIW"
"1SB1"
"1SFQ"
"1SG8"
"1SGI"
"1SHH"
"1SL3"
"1SR5"
"1T4U"
"1T4V"
"1TA2"
"1TA6"
"1TB6"
"1TBZ"
"1THP"
"1THR"
"1THS"
"1TMB"
"1TMT"
"1TMU"
"1TOM"
"1TQ0"
"1TQ7"
"1TWX"
"1UMA"
"1UVS"
"1VR1"
"1VZQ"
"1W7G"
"1WAY"
"1WBG"
"1XM1"
"1XMN"
"1YPE"
"1YPG"
"1YPJ"
"1YPK"
"1YPL"
"1YPM"
"1Z71"
"1Z8I"
"1Z8J"
"1ZGI"
"1ZGV"
"1ZRB"
"2A0Q"
"2A2X"
"2A45"
"2AFQ"
"2ANK"
"2ANM"
"2B5T"
"2BDY"
"2BVR"
"2BVS"
"2BVX"
"2BXT"
"2BXU"
"2C8W"
"2C8X"
"2C8Y"
"2C8Z"
"2C90"
"2C93"
"2CF8"
"2CF9"
"2CN0"
"2FEQ"
"2FES"
"2GDE"
"2GP9"
"2H9T"
"2HGT"
"2HNT"
"2HPP"
"2HPQ"
"2HWL"
"2JH0"
"2JH5"
"2JH6"
"2OD3"
"2PGB"
"2PGQ"
"2PKS"
"2PW8"
"2R2M"
"2THF"
"2UUF"
"2UUJ"
"2UUK"
"2V3H"
"2V3O"
"2ZC9"
"2ZDA"
"2ZDV"
"2ZF0"
"2ZFF"
"2ZFP"
"2ZFQ"
"2ZFR"
"2ZG0"
"2ZGB"
"2ZGX"
"2ZHE"
"2ZHF"
"2ZHQ"
"2ZHW"
"2ZI2"
"2ZIQ"
"2ZNK"
"2ZO3"
"3B23"
"3B9F"
"3BEF"
"3BEI"
"3BF6"
"3BIU"
"3BIV"
"3BV9"
"3C1K"
"3C27"
"3D49"
"3DA9"
"3DD2"
"3DHK"
"3DT0"
"3DUX"
"3E6P"
"3EE0"
"3EGK"
"3EQ0"
"3F68"
"3GIC"
"3GIS"
"3HAT"
"3HKJ"
"3HTC"
"3JZ1"
"3JZ2"
"3K65"
"3LDX"
"3LU9"
"3NXP"
"3P17"
"3P6Z"
"3P70"
"3PMH"
"3PO1"
"3QDZ"
"3QGN"
"3QLP"
"3QTO"
"3QTV"
"3QWC"
"3QX5"
"3R3G"
"3RLW"
"3RLY"
"3RM0"
"3RM2"
"3RML"
"3RMM"
"3RMN"
"3RMO"
"3S7H"
"3S7K"
"3SHA"
"3SHC"
"3SI3"
"3SI4"
"3SQE"
"3SQH"
"3SV2"
"3T5F"
"3TU7"
"3U69"
"3U8O"
"3U8R"
"3U8T"
"3U98"
"3U9A"
"3UTU"
"3UWJ"
"3VXE"
"3VXF"
"4AX9"
"4AYV"
"4AYY"
"4AZ2"
"4BAH"
"4BAK"
"4BAM"
"4BAN"
"4BAO"
"4BAQ"
"4BOH"
"4CH2"
"4CH8"
"4DIH"
"4DII"
"4DT7"
"4DY7"
"4E05"
"4E06"
"4E7R"
"4H6S"
"4H6T"
"4HFP"
"4HTC"
"4HZH"
"4I7Y"
"4LOY"
"4LXB"
"4LZ1"
"4LZ4"
"4MLF"
"4N3L"
"4NZE"
"4NZQ"
"4O03"
"4RKJ"
"4RKO"
"4RN6"
"4THN"
"4UD9"
"4UDW"
"4UE7"
"4UEH"
"4UFD"
"4UFE"
"4UFF"
"4UFG"
"4YES"
"5A2M"
"5AF9"
"5AFY"
"5AFZ"
"5AHG"
"5CMX"
"5E8E"
"5EDK"
"5EDM"
"5GDS"
"5JDU"
"7KME"
"8KME"
wdt:P646 "/m/01jn6k"
wdt:P652 "25ADE2236L"
wdt:P672 "D08.811.277.656.300.760.855"
"D08.811.277.656.959.350.855"
"D12.776.124.125.890"
"D23.119.960"
wdt:P680 serine-type peptidase activity
hydrolase activity
calcium ion binding
peptidase activity
signaling receptor binding
heparin binding
growth factor activity
serine-type endopeptidase activity
thrombospondin receptor activity
lipopolysaccharide binding
enzyme activator activity
protein binding
wdt:P681 extracellular space
endoplasmic reticulum lumen
external side of plasma membrane
extracellular region
Golgi lumen
blood microparticle
plasma membrane
collagen-containing extracellular matrix
extracellular exosome
wdt:P682 fibrinolysis
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of cell population proliferation
multicellular organism development
acute-phase response
G protein-coupled receptor signaling pathway
positive regulation of cell growth
negative regulation of proteolysis
positive regulation of reactive oxygen species metabolic process
regulation of cell shape
response to wounding
platelet activation
leukocyte migration
positive regulation of protein phosphorylation
cell surface receptor signaling pathway
positive regulation of receptor signaling pathway via JAK-STAT
blood coagulation, intrinsic pathway
negative regulation of platelet activation
peptidyl-glutamic acid carboxylation
regulation of blood coagulation
positive regulation of blood coagulation
positive regulation of collagen biosynthetic process
negative regulation of astrocyte differentiation
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
negative regulation of fibrinolysis
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of complement activation
regulation of signaling receptor activity
positive regulation of protein localization to nucleus
endoplasmic reticulum to Golgi vesicle-mediated transport
negative regulation of cytokine production involved in inflammatory response
signal peptide processing
blood coagulation
positive regulation of lipid kinase activity
blood coagulation, fibrin clot formation
antimicrobial humoral immune response mediated by antimicrobial peptide
proteolysis
regulation of gene expression
hemostasis
wdt:P702 F2
wdt:P703 man
wdt:P705 "ENSP00000308541"
"ENSP00000387413"
"ENSP00000433907"
wdt:P8189 "987007536583605171"
wdt:P8313 "thrombin"
wdt:P8408 "SerineProtease"
wdt:P8814 "14761428-n"
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