Interleukin 6

mammalian protein found in Homo sapiens
rdfs:label
"Interleukin 6"@en
skos:altLabel
"B-cell differentiation factor"@en
"B-cell stimulatory factor 2"@en
"BSF-2"@en
"CDF"@en
"CTL differentiation factor"@en
"IFN-beta-2"@en
"IL6"@en
"hybridoma growth factor"@en
"interferon beta-2"@en
"interleukin BSF-2"@en
"interleukin-6"@en
schema:description
"mammalian protein found in Homo sapiens"@en
schema:dateModified "2026-10-16T21:28:48+00:00"^^xsd:dateTime
schema:version 2557749357
wikibase:identifiers 27
wikibase:sitelinks 25
wikibase:statements 100
p:P10283 wd:statement/Q412889-25C86D27-DA6E-4B65-A891-790C45D699B4
p:P18 wd:statement/Q412889-47EAD659-91CD-46D7-A381-D2A5AD15DAA1
p:P2888 wd:statement/Q412889-0C413758-671A-4E7B-8A1C-A418D49B9F6C
p:P31 wd:statement/Q412889-7502C1B0-4AFB-425C-BEFA-43F29955E894
p:P352 wd:statement/q412889-47311D11-4AA1-46FA-895F-0CFDACDDF8D1
p:P361 wd:statement/Q412889-6626DE4F-F3D6-4D30-9C51-B1A10BC1D64B
wd:statement/Q412889-67F24D95-3D1B-444E-B2C5-281C19828CB6
wd:statement/Q412889-EA5FBC51-8919-4450-B386-794F8AE8E496
p:P508 wd:statement/Q412889-C79E1667-57FA-43EA-8ED9-B293276150F9
p:P527 wd:statement/Q412889-69CF751F-BCC6-4071-9140-F8C9691A8E45
p:P6366 wd:statement/Q412889-726A44AD-941F-473A-9E09-FC09A6C0E540
p:P637 wd:statement/Q412889-8B2EFECD-267F-4981-AE31-DD933EA3AE1E
wd:statement/Q412889-95612D1A-8163-45C9-8B9C-57FE799F3A26
wd:statement/Q412889-97F40E55-2BE7-45FB-944D-CFCF3D0BD30B
wd:statement/Q412889-9EC93F40-011D-49C3-97C4-FCC53BA1A3DD
wd:statement/Q412889-BC598273-D4FA-4DC1-8161-EC5DC5691574
p:P638 wd:statement/Q412889-015CDB22-757A-413C-85E3-20E46E7307C3
wd:statement/Q412889-3AD90D80-F339-4C6E-9B30-3972CE8DEF04
wd:statement/Q412889-45458434-365A-4061-904A-2F31580D1134
wd:statement/Q412889-4B236D55-D63C-4693-A023-2806B9720D73
wd:statement/Q412889-582662CE-B847-4748-8E3D-4DC22B676845
wd:statement/Q412889-8116CE3A-787A-44E7-B970-DF516EAC9E8D
wd:statement/Q412889-83B2F6B3-ABB8-47CA-B42F-9D6DC50DA2A9
wd:statement/Q412889-8C94E5D9-B263-46EB-99CA-4BEE5BC957B5
wd:statement/Q412889-8D145C25-0124-4CC7-BF78-5F5DB1B449A7
wd:statement/Q412889-EB838E52-94D2-45B7-97B3-66FF5575A421
p:P646 wd:statement/Q412889-B085D4EB-07F4-40DF-B6AA-4F4EACFC4679
p:P680 wd:statement/Q412889-2CAE9F7D-A5FD-4A75-B359-433EFA8617B1
wd:statement/Q412889-A49E0933-FC11-4A79-8E73-1C666E36E745
wd:statement/Q412889-B9E69837-9ED4-4026-906A-4C2506C6C8CF
wd:statement/Q412889-FAD23C37-F0E2-4249-9EDF-DFE444C10AC7
p:P681 wd:statement/Q412889-06DE0170-3A45-4751-A7D9-2975F6523DA5
wd:statement/Q412889-C4A0C6ED-A487-4FBB-9336-3A3AB53B6CD5
wd:statement/Q412889-F23C7EEE-92B5-42D9-A4D2-4199A7EE1248
wd:statement/Q412889-FEC6ABB9-3F96-410E-BFD0-A6DD7E8C9CB8
p:P682 wd:statement/Q412889-07BD5792-33AA-4679-9EF6-51276C6E7D2A
wd:statement/Q412889-12CD4925-3518-4F87-B2B4-3104C5DFAC87
wd:statement/Q412889-17AC35FB-6B87-4110-BA30-0976F59F7C8C
wd:statement/Q412889-18973E68-0EA7-441E-A6BC-ADFDD8936242
wd:statement/Q412889-1DCEE327-0C29-4F30-BEE2-63EFF0657953
wd:statement/Q412889-231C7EB3-3230-436B-B8E4-30AEFD5AE3D7
wd:statement/Q412889-28F0E46C-43FE-446A-A49E-25C2943196D5
wd:statement/Q412889-2A713252-9EA1-472D-B504-7D6DBC8695B4
wd:statement/Q412889-2F048FB5-D8B7-4586-94D1-B37B6F93A217
wd:statement/Q412889-34A07FBD-83BB-4590-A87F-0DB77A3AFBB4
wd:statement/Q412889-37958369-93B9-4000-8F64-E69249DFC0CB
wd:statement/Q412889-3C95DE93-7707-43E8-8A8E-FAC17CB32106
wd:statement/Q412889-3D50BC41-016D-4626-BDEA-5B3764C58EA0
wd:statement/Q412889-4507CBD8-3341-4405-81F2-BF1FE9A586B7
wd:statement/Q412889-494729B0-FFA9-438F-BB15-7651B5A621FE
wd:statement/Q412889-4A4ABF35-1FCC-4AEF-A65E-FE1B4B3C0718
wd:statement/Q412889-50CA9D61-0C09-43BD-ABB9-8E887A4B0D40
wd:statement/Q412889-60691111-6B87-414F-9C2B-30BAF8CCA600
wd:statement/Q412889-64231C0E-73CB-42D8-90E8-C7CFC320A88A
wd:statement/Q412889-697EBD91-27F7-4DFF-8A34-1375F26B1E15
wd:statement/Q412889-6D85E037-3C5A-427D-BF71-DD69359F54BF
wd:statement/Q412889-6E6CEF6A-7E0B-45A6-8577-C0A745C5D8EF
wd:statement/Q412889-7136BF44-4618-4E57-A8DF-DC2D93DCD325
wd:statement/Q412889-7739E1A6-14A5-48F2-8BCF-3A31B5F67121
wd:statement/Q412889-7DC8F9E1-2AC7-4567-A538-9F412BA1126E
wd:statement/Q412889-7EFD0EF7-1509-4EC0-8FB2-CA6E07966135
wd:statement/Q412889-7F01B637-B414-4345-8CAF-60A9AF0B8F86
wd:statement/Q412889-81E0E2FB-183A-484E-8294-9B65EF26B177
wd:statement/Q412889-82D5E59A-42CC-49ED-B9F0-7DCDC2074E48
wd:statement/Q412889-85B500B0-B338-4400-AF92-5DBD6813B714
wd:statement/Q412889-8B6F9512-DC58-4AC1-8FAC-6CEE0D0E5152
wd:statement/Q412889-8F48E2FE-B798-473A-8550-BFFE6A68DFE1
wd:statement/Q412889-927CC67F-08F4-4982-8B1E-67533BAC58C5
wd:statement/Q412889-93A4E881-4579-48D5-AC0D-3CCE917AC5A5
wd:statement/Q412889-93AF9847-7F93-4365-BB44-4AAD259C4745
wd:statement/Q412889-94728292-2C73-4F66-B9E4-E50CB35CA66D
wd:statement/Q412889-99C4E45B-E997-4994-A3EC-F49B7E7E9E1C
wd:statement/Q412889-9B16A533-3DBF-41A6-961D-84802FCDB003
wd:statement/Q412889-A03933E1-084C-42EA-A4A0-9BD74E3F25C0
wd:statement/Q412889-A1D8CC0F-59A3-4828-B26C-884D39514ED4
wd:statement/Q412889-A3FA0EBD-F2AC-4AA2-A365-CA9E5933B225
wd:statement/Q412889-B45B278B-2110-4BD3-9F71-F020A9B33672
wd:statement/Q412889-BE280C16-5940-4B4A-96F8-E0A00AA972AD
wd:statement/Q412889-C44FF7C6-9A3F-4663-9733-33A0B9E9048A
wd:statement/Q412889-C47A1DED-306C-43BF-A06E-231C83BF0662
wd:statement/Q412889-C4AD925F-C222-4DF7-AB21-BEB6CC83FC16
wd:statement/Q412889-CC72F800-2F5B-4F98-B5A8-E0F7D3666B4E
wd:statement/Q412889-D2E85444-0FD1-4175-8655-186B9C9F225F
wd:statement/Q412889-DA35070A-BD24-4CC9-A487-7E515BA150D8
wd:statement/Q412889-DC805F5B-F346-40F4-8DE3-0FE4D1D64C90
wd:statement/Q412889-DDC9396D-727D-43DD-9EBA-3EC3B4E5E8E9
wd:statement/Q412889-DDE65ABE-A9D4-45DB-9352-34AF8C134E5F
wd:statement/Q412889-DEA21A78-739C-44AD-88BC-D054014C1AF4
wd:statement/Q412889-E7F56A4F-38AB-4A1C-B7C5-30B4A3A22F42
wd:statement/Q412889-ECB2FC5D-8EB2-4CEE-B5EE-89A826D224BD
wd:statement/Q412889-F656AC16-8A2B-4826-A967-E51C7E0389A1
p:P702 wd:statement/q412889-066CE867-2C1F-40D4-81F6-070CFF5416C3
p:P703 wd:statement/Q412889-4FF891DF-4BEB-4D08-9C1B-32521255080F
p:P705 wd:statement/Q412889-05718AC0-AFC6-4234-826E-D2E0121DF919
wd:statement/Q412889-07F35C8F-9163-46CE-9B4F-639BE1E81AF9
wd:statement/Q412889-2DA83610-5E24-4617-9331-5C1553DEF447
wd:statement/Q412889-42BFDF40-A29E-45FA-B815-F5C62E9F6B6F
wd:statement/Q412889-44713B3A-A835-4469-A27C-7A631B3C69BE
wd:statement/Q412889-9A35BCF9-A4DC-4586-94DE-EA6FEA7104BB
wd:statement/q412889-9060EC5A-F26B-472D-B8DF-82B64623B4E8
p:direct-normalized/P352 <http://purl.uniprot.org/uniprot/P05231>
p:direct-normalized/P508 <http://purl.org/bncf/tid/73989>
p:direct-normalized/P6366 <https://makg.org/entity/11988809>
p:direct-normalized/P637 <http://purl.uniprot.org/refseq/NP_000591>
<http://purl.uniprot.org/refseq/NP_001305024>
<http://purl.uniprot.org/refseq/NP_001358025>
<http://purl.uniprot.org/refseq/XP_005249802>
<http://purl.uniprot.org/refseq/XP_011513692>
p:direct-normalized/P638 <https://rdf.wwpdb.org/pdb/1ALU>
<https://rdf.wwpdb.org/pdb/1IL6>
<https://rdf.wwpdb.org/pdb/1P9M>
<https://rdf.wwpdb.org/pdb/2IL6>
<https://rdf.wwpdb.org/pdb/4CNI>
<https://rdf.wwpdb.org/pdb/4J4L>
<https://rdf.wwpdb.org/pdb/4NI7>
<https://rdf.wwpdb.org/pdb/4NI9>
<https://rdf.wwpdb.org/pdb/4O9H>
<https://rdf.wwpdb.org/pdb/4ZS7>
wdt:P10283 "C11988809"
wdt:P18 <http://commons.wikimedia.org/wiki/Special:FilePath/IL6%20Crystal%20Structure.rsh.png>
wdt:P2888 <http://purl.uniprot.org/uniprot/P05231>
wdt:P31 protein
wdt:P352 "P05231"
wdt:P361 four-helical cytokine-like, core
interleukin-6
Interleukin-6/GCSF/MGF, conserved site, protein family
wdt:P508 "73989"
wdt:P527 Interleukin-6/GCSF/MGF, conserved site
wdt:P6366 "11988809"
wdt:P637 "NP_000591"
"NP_001305024"
"NP_001358025"
"XP_005249802"
"XP_011513692"
wdt:P638 "1ALU"
"1IL6"
"1P9M"
"2IL6"
"4CNI"
"4J4L"
"4NI7"
"4NI9"
"4O9H"
"4ZS7"
wdt:P646 "/m/05gpxj"
wdt:P680 growth factor activity
cytokine activity
interleukin-6 receptor binding
protein binding
wdt:P681 extracellular space
endoplasmic reticulum lumen
extracellular region
interleukin-6 receptor complex
wdt:P682 positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of cell population proliferation
negative regulation of apoptotic process
positive regulation of cell population proliferation
positive regulation of gene expression
acute-phase response
endocrine pancreas development
positive regulation of MAPK cascade
positive regulation of NF-kappaB transcription factor activity
positive regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
platelet activation
inflammatory response
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of peptidyl-serine phosphorylation
response to glucocorticoid
negative regulation of lipid storage
monocyte chemotaxis
negative regulation of bone resorption
cytokine-mediated signaling pathway
cellular response to lipopolysaccharide
humoral immune response
defense response to virus
positive regulation of osteoblast differentiation
positive regulation of smooth muscle cell proliferation
neutrophil mediated immunity
negative regulation of fat cell differentiation
regulation of angiogenesis
positive regulation of translation
neuron projection development
positive regulation of DNA-binding transcription factor activity
positive regulation of T cell proliferation
positive regulation of interleukin-6 production
defense response to Gram-positive bacterium
positive regulation of leukocyte chemotaxis
neutrophil apoptotic process
hepatic immune response
positive regulation of acute inflammatory response
regulation of vascular endothelial growth factor production
response to peptidoglycan
positive regulation of chemokine production
negative regulation of collagen biosynthetic process
defense response to Gram-negative bacterium
positive regulation of B cell activation
glucagon secretion
interleukin-6-mediated signaling pathway
cellular response to hydrogen peroxide
regulation of signaling receptor activity
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of interleukin-1-mediated signaling pathway
immune response
positive regulation of type B pancreatic cell apoptotic process
T-helper 17 cell lineage commitment
positive regulation of T-helper 2 cell cytokine production
post-translational protein modification
wdt:P702 IL6
wdt:P703 man
wdt:P705 "ENSP00000258743"
"ENSP00000384928"
"ENSP00000385043"
"ENSP00000385227"
"ENSP00000385675"
"ENSP00000385718"
"ENSP00000405150"
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