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rdfs:label
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"COX-2"@it
"COX-2"@pl
"COX-2"@pt
"Ciclooxixenase 2"@gl
"Ciklooxigenáz 2"@hu
"Cyclo-oxygenase 2"@nl
"Cyclooxygenase-2"@de
"Cyclooxygénase 2"@fr
"PTGS2"@cy
"PTGS2"@es
"PTGS2"@uk
"Prostaglandin-endoperoxide synthase 2"@en
"Siklooksigenase-2"@id
"cyklooxygenáza 2"@cs
"prostaglandin-endoperoksid sintaza 2"@sl
"シクロオキシゲナーゼ2"@ja
"고리형 산소화효소-2"@ko
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skos:altLabel
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"COX 2"@es
"COX-2"@en
"COX-2"@de
"COX-2"@es
"Ciclooxigenasa 2"@es
"Cyclooxygenase 2"@de
"Cyclooxygenase-2"@en
"Cyklooksygenaza indukowana"@pl
"Cyklooksygenaza wzbudzona"@pl
"Cyklooksygenaza-2"@pl
"PGH synthase 2"@en
"PGHS-2"@en
"PHS II"@en
"PTGS2"@en
"PTGS2"@pt
"Prostaglandin-endoperoxide synthase 2"@pt
"cyclooxygenase 2"@en
"cyclooxygenase 2b"@en
"prostaglandin G/H synthase 2"@en
"prostaglandin H2 synthase 2"@en
"prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)"@en
"プロスタグランジン-エンドペルオキシド合成酵素2"@ja
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schema:description
|
"Protein"@de
"enzima"@it
"enzyme"@fr
"human enzyme involved in inflammation"@en
"protein"@sv
"protein"@id
"proteinë"@sq
"proteïne in Cyclo-oxygenase 2"@nl
"protèin"@ace
"بروتين في الإنسان العاقل"@ar
"산화환원효소의 종류"@ko
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schema:dateModified
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"2026-08-17T14:06:28+00:00"^^xsd:dateTime
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schema:version
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2532355986
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wikibase:identifiers
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15
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wikibase:sitelinks
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16
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p:P691
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wd:statement/Q415364-AF48573E-2847-40D8-A2F0-ED29998A0D2A
|
|
p:P702
|
wd:statement/Q415364-B02A4153-A357-42D1-A748-96BE7939F8D0
|
|
p:P703
|
wd:statement/Q415364-9B3C4110-452E-40CB-B220-C1A01DC7C9C8
|
|
p:P705
|
wd:statement/Q415364-4DC72AF4-AC7F-4BCF-B3F3-7DE772EC03B6
|
|
wd:statement/Q415364-F7D4879B-40DC-44B6-A8FE-68B1829B27FF
|
|
p:direct-normalized/P352
|
<http://purl.uniprot.org/uniprot/P35354>
|
|
p:direct-normalized/P6366
|
<https://makg.org/entity/2777350520>
|
|
p:direct-normalized/P637
|
<http://purl.uniprot.org/refseq/NP_000954>
|
|
p:direct-normalized/P638
|
<https://rdf.wwpdb.org/pdb/5F19>
|
|
<https://rdf.wwpdb.org/pdb/5F1A>
|
|
<https://rdf.wwpdb.org/pdb/5IKQ>
|
|
<https://rdf.wwpdb.org/pdb/5IKR>
|
|
<https://rdf.wwpdb.org/pdb/5IKT>
|
|
<https://rdf.wwpdb.org/pdb/5IKV>
|
|
wdt:P129
|
naproxen
|
|
diclofenac sodium
|
|
iguratimod
|
|
oxaprozin
|
|
apricoxib
|
|
aspirin
|
|
ibuprofen
|
|
polmacoxib
|
|
ketorolac
|
|
nimesulide
|
|
isoxicam
|
|
Diclofenac
|
|
(RS)-etodolac
|
|
bromfenac
|
|
(RS)-fenoprofen
|
|
diflunisal
|
|
esflurbiprofen
|
|
diclofenac potassium
|
|
(RS)-fenoprofen calcium dihydrate
|
|
ketorolac tromethamine
|
|
naproxen sodium
|
|
tolmetin sodium
|
|
meclofenamic acid
|
|
mefenamic acid
|
|
valdecoxib
|
|
suprofen
|
|
resveratrol
|
|
piroxicam
|
|
celecoxib
|
|
(RS)-ketoprofen
|
|
rofecoxib
|
|
lumiracoxib
|
|
meloxicam
|
|
(±)-flurbiprofen
|
|
phenylbutazone
|
|
benzquinamide
|
|
paracetamol
|
|
etoricoxib
|
|
NS-398
|
|
carprofen
|
|
wdt:P1417
|
"science/cyclooxygenase-2"
|
|
wdt:P18
|
<http://commons.wikimedia.org/wiki/Special:FilePath/6COX.png>
|
|
wdt:P2888
|
<http://purl.uniprot.org/uniprot/P35354>
|
|
wdt:P31
|
protein
|
|
wdt:P352
|
"P35354"
|
|
wdt:P354
|
"9605"
|
|
wdt:P361
|
Haem peroxidase superfamily
|
|
Prostaglandin G/H synthase 2
|
|
Haem peroxidase domain superfamily, animal type
|
|
EGF-like domain, protein family
|
|
wdt:P373
|
"Cyclooxygenase 2"
|
|
wdt:P527
|
EGF-like domain
|
|
wdt:P591
|
"1.14.99.1"
|
|
wdt:P6366
|
"2777350520"
|
|
wdt:P637
|
"NP_000954"
|
|
wdt:P638
|
"5F19"
|
|
"5F1A"
|
|
"5IKQ"
|
|
"5IKR"
|
|
"5IKT"
|
|
"5IKV"
|
|
wdt:P646
|
"/m/02x2zj9"
|
|
wdt:P680
|
metal ion binding
|
|
oxidoreductase activity
|
|
heme binding
|
|
enzyme binding
|
|
protein homodimerization activity
|
|
peroxidase activity
|
|
transferase activity
|
|
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
|
prostaglandin-endoperoxide synthase activity
|
|
arachidonate 15-lipoxygenase activity
|
|
protein binding
|
|
dioxygenase activity
|
|
wdt:P681
|
caveola
|
|
endoplasmic reticulum membrane
|
|
membrane
|
|
intracellular membrane-bounded organelle
|
|
endoplasmic reticulum lumen
|
|
neuron projection
|
|
organelle membrane
|
|
protein-containing complex
|
|
cytoplasm
|
|
endoplasmic reticulum
|
|
wdt:P682
|
decidualization
|
|
learning
|
|
response to lipopolysaccharide
|
|
positive regulation of synaptic transmission, glutamatergic
|
|
response to oxidative stress
|
|
negative regulation of cell population proliferation
|
|
negative regulation of apoptotic process
|
|
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
|
bone mineralization
|
|
response to vitamin D
|
|
response to tumor necrosis factor
|
|
positive regulation of cell population proliferation
|
|
response to estradiol
|
|
positive regulation of nitric oxide biosynthetic process
|
|
positive regulation of brown fat cell differentiation
|
|
cellular response to UV
|
|
positive regulation of apoptotic process
|
|
cellular response to hypoxia
|
|
regulation of cell population proliferation
|
|
brown fat cell differentiation
|
|
regulation of blood pressure
|
|
inflammatory response
|
|
positive regulation of cell death
|
|
positive regulation of prostaglandin biosynthetic process
|
|
positive regulation of peptidyl-serine phosphorylation
|
|
positive regulation of vasoconstriction
|
|
response to glucocorticoid
|
|
response to organic cyclic compound
|
|
positive regulation of protein import into nucleus
|
|
embryo implantation
|
|
cellular response to mechanical stimulus
|
|
fatty acid biosynthetic process
|
|
negative regulation of smooth muscle contraction
|
|
regulation of inflammatory response
|
|
response to cytokine
|
|
negative regulation of synaptic transmission, dopaminergic
|
|
fatty acid metabolic process
|
|
response to organic substance
|
|
cytokine-mediated signaling pathway
|
|
response to radiation
|
|
positive regulation of smooth muscle cell proliferation
|
|
response to organonitrogen compound
|
|
positive regulation of smooth muscle contraction
|
|
positive regulation of transforming growth factor beta production
|
|
positive regulation of fever generation
|
|
negative regulation of calcium ion transport
|
|
negative regulation of cell cycle
|
|
positive regulation of vascular endothelial growth factor production
|
|
cellular response to heat
|
|
cyclooxygenase pathway
|
|
prostaglandin biosynthetic process
|
|
prostaglandin metabolic process
|
|
lipoxygenase pathway
|
|
response to lithium ion
|
|
positive regulation of cell migration involved in sprouting angiogenesis
|
|
response to fatty acid
|
|
long-chain fatty acid biosynthetic process
|
|
response to manganese ion
|
|
NAD biosynthesis via nicotinamide riboside salvage pathway
|
|
response to fructose
|
|
positive regulation of synaptic plasticity
|
|
maintenance of blood-brain barrier
|
|
ovulation
|
|
cellular response to ATP
|
|
cellular response to fluid shear stress
|
|
positive regulation of fibroblast growth factor production
|
|
cellular response to lead ion
|
|
positive regulation of platelet-derived growth factor production
|
|
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
|
|
cellular oxidant detoxification
|
|
cellular response to non-ionic osmotic stress
|
|
response to angiotensin
|
|
hair cycle
|
|
sensory perception of pain
|
|
lipid metabolism
|
|
ageing
|
|
memory
|
|
angiogenesis
|
|
regulation of neuroinflammatory response
|
|
wdt:P691
|
"ph430281"
|
|
wdt:P702
|
PTGS2
|
|
wdt:P703
|
man
|
|
wdt:P705
|
"ENSP00000356438"
|
|
"ENSP00000454130"
|
