SHMARQL

3-hydroxy-3-methylglutaryl-CoA reductase

<http://www.wikidata.org/entity/Q415607>

mammalian protein found in Homo sapiens
3-hydroxy-3-methylglutaryl-CoA reductase
rdfs:label
"3-hydroxy-3-methylglutaryl-CoA reductase"@en
skos:altLabel
"3-hydroxy-3-methylglutaryl CoA reductase (NADPH)"@en
"3-hydroxy-3-methylglutaryl-Coenzyme A reductase"@en
"Entrez P04035"@en
"HMG-CoA reductase"@en
"HMGCR"@en
"hydroxymethylglutaryl-CoA reductase"@en
schema:description
"mammalian protein found in Homo sapiens"@en
schema:dateModified "2026-09-27T21:26:47+00:00"^^xsd:dateTime
schema:version 2550174829
wikibase:identifiers 41
wikibase:sitelinks 25
wikibase:statements 116
p:P10283 wd:statement/Q415607-90C90BE8-64BE-48E5-B052-1F575435C2CD
p:P129 wd:statement/Q415607-047789F8-09AA-4673-AF1F-63166A8CAF3F
wd:statement/Q415607-4B2584F1-C2C4-45DF-8749-E6C8B146B7A1
wd:statement/Q415607-4C16FBD7-30BB-46B4-A519-CC75F216452D
wd:statement/Q415607-5E50524E-5FBC-458A-BE6F-CC22AF58090B
wd:statement/Q415607-6E1D6DAE-421B-4FDD-9AB8-37694E1D9CD7
wd:statement/Q415607-98363E4E-6253-4DD0-9109-5C7EF6C14579
wd:statement/Q415607-B0ED4901-0098-4EEF-B14C-1203F2EF75E1
wd:statement/Q415607-D8499F8D-6F55-439B-82FB-EC4F5AAB5DBC
p:P18 wd:statement/Q415607-C4D090CD-CA92-48E3-BE7D-0921AC932151
p:P227 wd:statement/Q415607-FC3622AE-25DB-4BA5-802A-B61DBF11EB31
p:P2888 wd:statement/Q415607-1D5AE447-0106-48BF-9E45-A74999D05D0E
p:P31 wd:statement/Q415607-530FDE45-7653-4C3E-8EF9-E39759FE7728
p:P352 wd:statement/q415607-5B474300-2950-40C6-A1A1-50CD557ACEAF
p:P361 wd:statement/Q415607-10157F4B-E247-4D72-827B-9784F9DA3F3E
wd:statement/Q415607-13828E40-32DC-4944-A440-92F474D94915
wd:statement/Q415607-177BC613-A41F-4C75-90E3-800445E56189
wd:statement/Q415607-3A7CE287-2A2D-4070-8DCC-9117860A0C88
wd:statement/Q415607-551C2DBB-17C9-46A5-9290-D5F79E803D9A
wd:statement/Q415607-A578064B-A4E0-45CD-BA1A-506D2DE901E9
wd:statement/Q415607-A9EE1741-B62F-4316-84E4-F62C34DC7B87
wd:statement/Q415607-B1E3EAD5-AE53-452D-87C9-167FCBFF9992
p:P373 wd:statement/Q415607-8edde0e8-bee7-425c-ba1f-b0218befe6c5
p:P527 wd:statement/Q415607-24CE0EE6-7A84-477F-A0C0-BCD079A9966A
wd:statement/Q415607-3795BBB3-450D-4AA2-8B48-2254E74B5416
p:P591 wd:statement/Q415607-25345800-3079-4A80-B1E6-8A3F4A16B771
p:P6366 wd:statement/Q415607-F89B13D1-F79C-428C-95B2-6CD16A43B194
p:P637 wd:statement/Q415607-569F78BF-2259-4086-9507-3E3D6A8CF2DA
wd:statement/Q415607-607D988C-6268-47E2-9462-FFC389238286
wd:statement/Q415607-7BB37B3E-228F-441F-BCD0-4AC77F1076AD
wd:statement/Q415607-8D3FB386-E54C-4AE6-AB26-F93B0F981A5D
wd:statement/Q415607-A90F2010-DE45-4753-BFF1-923DD22B3EA2
wd:statement/Q415607-F058A311-5734-432A-9D80-C3C822670BC4
p:P638 wd:statement/q415607-0FD56E26-CE73-41C7-8641-7254209119E7
wd:statement/q415607-340747BA-2D67-49FB-99CD-50B1E55699AC
wd:statement/q415607-36B2519D-543A-4245-B0BC-6D91B241E98C
wd:statement/q415607-38939297-E6E4-4871-94A4-A96FD0AC0125
wd:statement/q415607-43A1C031-DE99-41F8-BBDC-DB4C648F2497
wd:statement/q415607-5A6A3907-4C34-47AA-9EBD-20701AB92C77
wd:statement/q415607-5BDA4C63-A15F-4075-8931-448BC089C970
wd:statement/q415607-71CFDD55-5766-41E9-A8EA-1E496BD4DF5C
wd:statement/q415607-7E536FE1-A61D-4359-9E21-9272E7D6AAFB
wd:statement/q415607-90DF0835-2DF8-4B98-AC17-3719DA3FD0D0
wd:statement/q415607-9C0DC0C0-C93B-4049-9C3A-D12E2F2B2447
wd:statement/q415607-A2ABE249-DCC4-4B96-B110-14CAF6E5943C
wd:statement/q415607-BCFFD791-2BB3-4B1E-971D-247D224CE901
wd:statement/q415607-BEFC89E2-8E73-4578-9FA4-AB6F7446AFC5
wd:statement/q415607-C26FFEB9-F670-4773-A2E8-F0FEFF4814CC
wd:statement/q415607-C45B236C-70DB-430F-8137-DAA41CF18116
wd:statement/q415607-C520D3A8-0BA8-41C8-93B0-2D0BD9FAC14D
wd:statement/q415607-C94E9836-B0FA-4CBB-BC19-840AEE9B4CD8
wd:statement/q415607-D2E2C76A-132A-4201-BEB5-D9311920DBB0
wd:statement/q415607-DFB9B81D-F7AC-4A17-958E-49DB90A22520
wd:statement/q415607-E50F378B-C7DA-4D1B-AA37-E3ED04F4E181
wd:statement/q415607-ECEBD7DA-4ADA-49AF-BC95-DC1DF739E2D9
p:P646 wd:statement/Q415607-ED7D2153-78A6-43DE-AA4F-9495D4FA7D9C
p:P680 wd:statement/Q415607-2976F666-E01C-4E9F-99B5-62618FD20D18
wd:statement/Q415607-3B3A4D15-7726-4DA9-8439-CD13592DE074
wd:statement/Q415607-3BDD7B05-9058-46E0-8128-59852553DCC6
wd:statement/Q415607-5160D6A7-F6BB-4EC8-82CD-EB3B91A6105C
wd:statement/Q415607-757464F3-2BA1-40C5-BE10-B308A3213F37
wd:statement/Q415607-7BE5D306-5640-4E22-B35C-D6EA44DDD693
wd:statement/Q415607-BAF8F422-BD5F-428D-9056-81BE687EDC8B
wd:statement/Q415607-F544D33D-1F7A-45EA-93CE-A19E001FE5FA
p:P681 wd:statement/Q415607-15945353-7CEC-4D58-A9FA-760D12C86031
wd:statement/Q415607-481D0657-BDF7-4B69-87C5-08B71F99D980
wd:statement/Q415607-6DCC5694-F5C8-4F23-A3B1-4967DAAD1FF9
wd:statement/Q415607-9D751E3A-D18E-4F28-95EB-FC80729F23A7
wd:statement/Q415607-A407881D-30E0-4551-8B59-D129CBD21F44
wd:statement/Q415607-BDEB8895-3060-490B-8656-355CC7BC121C
wd:statement/Q415607-E181E53B-9B54-45F3-8C11-F01273D03823
wd:statement/Q415607-E32D5D99-D99D-4E8F-90FD-D6C903951D86
p:P682 wd:statement/Q415607-049B7F80-E7F5-4D84-A3AF-4BA696F7622F
wd:statement/Q415607-05FBEC13-05DF-4BD2-821C-363B13EC2C81
wd:statement/Q415607-09BB8D3B-F74D-4C05-958E-6C6BECA03726
wd:statement/Q415607-0ABC2130-38C8-4A09-AE9E-AEAD78D94E3C
wd:statement/Q415607-10F07B45-94F0-4CAD-896C-DD32FDE8FAE8
wd:statement/Q415607-1BEDCC83-7AE8-4A99-932A-D6F3CCE97A48
wd:statement/Q415607-1CB1BD87-5F6D-4722-B06A-D70ADBB12C53
wd:statement/Q415607-20589FC9-48BF-480B-9BDB-93F7D6905D3D
wd:statement/Q415607-3F829CD0-84CF-4312-9604-173AA30D328C
wd:statement/Q415607-4202028B-8E48-4764-A1C7-FD22D62DBFF3
wd:statement/Q415607-42850208-4A41-4E6B-83DF-E1C6B817CD0B
wd:statement/Q415607-450CC6CA-154B-4A4D-A82C-9A5607D734F5
wd:statement/Q415607-526A681F-D89D-45E9-AE59-A635A401EF89
wd:statement/Q415607-5ABF79F4-7126-4A70-99F7-586BEA960F0B
wd:statement/Q415607-5DDB4C16-53DC-4D13-8230-DB0379DF6FBB
wd:statement/Q415607-60380E59-A598-4C82-A49A-AE7AF92D4E59
wd:statement/Q415607-63098F8C-BFA9-4B34-ADA9-A023ECF5D0E2
wd:statement/Q415607-7A80A68C-93A7-4A8C-9442-978D73F34E25
wd:statement/Q415607-9C41F4E4-446F-48FC-94D3-6643BEBEB3A9
wd:statement/Q415607-9FFF88EA-4ABD-4F0C-833F-C888E75E1A52
wd:statement/Q415607-A2620EE3-62D9-49E1-916C-3BA269EAA626
wd:statement/Q415607-A444E61D-72BC-476F-9D64-5FCCCFDD0F2A
wd:statement/Q415607-A4C70114-5894-4A98-BEAF-F3C4131C5E00
wd:statement/Q415607-ABF182DA-3FBC-48AA-B740-3EE97F0BDBBA
wd:statement/Q415607-AE5F26C6-899A-4E05-8416-B069B5A95536
wd:statement/Q415607-B1572364-23BA-4DBE-B6CC-5AA64575292E
wd:statement/Q415607-BF17F7AF-1A59-4DE0-9C6E-B389E1FA6B9B
wd:statement/Q415607-C2E473EE-096E-4299-B5A2-2A4F3271896D
wd:statement/Q415607-CC5B1F5C-B9D5-4549-B7FA-AFBD45BB2F17
wd:statement/Q415607-CCE0CBD2-A54E-4A5D-8FE4-3C8B4CD302C8
wd:statement/Q415607-E5529715-4D48-4DE5-A84C-9B7813414757
wd:statement/Q415607-F1BFD681-4898-45F8-AF2E-93023848A6E7
wd:statement/Q415607-FEC23C82-DCFA-438D-8F9D-EFBA9E298E63
p:P692 wd:statement/Q415607-074FD992-E316-4AE0-A08E-CA664F05A964
p:P702 wd:statement/q415607-DDD045DC-4BE8-4708-B905-F6A18DC59E55
p:P703 wd:statement/Q415607-A06ACB36-96BA-4210-86FA-04E2F8726532
p:P705 wd:statement/Q415607-5C7A1988-E05A-4E0D-B89A-D18EFF99803C
wd:statement/Q415607-5E16D62A-4157-4A24-A5A5-406BA72A6018
wd:statement/Q415607-B2335FDD-BA95-4190-85C5-CECC4A5C73DC
wd:statement/Q415607-E6C85F14-8DA4-47BF-9F21-EB8AE294E7E0
wd:statement/q415607-2DC3518C-9948-4F99-AEA5-CF11602F7DF8
wd:statement/q415607-98C1F089-30C4-4575-A3EA-CF9BA60ECF3F
wd:statement/q415607-EACBE21B-5330-4D3D-96A8-7C9E3FA7A757
p:P7260 wd:statement/Q415607-0E9CD32A-55D3-428A-A36F-80EADE6D51C5
p:direct-normalized/P227 <https://d-nb.info/gnd/4161000-3>
p:direct-normalized/P352 <http://purl.uniprot.org/uniprot/P04035>
p:direct-normalized/P6366 <https://makg.org/entity/104950815>
p:direct-normalized/P637 <http://purl.uniprot.org/refseq/NP_000850>
<http://purl.uniprot.org/refseq/NP_001124468>
<http://purl.uniprot.org/refseq/NP_001351116>
<http://purl.uniprot.org/refseq/XP_011541659>
<http://purl.uniprot.org/refseq/XP_011541660>
<http://purl.uniprot.org/refseq/XP_011541661>
p:direct-normalized/P638 <https://rdf.wwpdb.org/pdb/1DQ8>
<https://rdf.wwpdb.org/pdb/1DQ9>
<https://rdf.wwpdb.org/pdb/1DQA>
<https://rdf.wwpdb.org/pdb/1HW8>
<https://rdf.wwpdb.org/pdb/1HW9>
<https://rdf.wwpdb.org/pdb/1HWI>
<https://rdf.wwpdb.org/pdb/1HWJ>
<https://rdf.wwpdb.org/pdb/1HWK>
<https://rdf.wwpdb.org/pdb/1HWL>
<https://rdf.wwpdb.org/pdb/2Q1L>
<https://rdf.wwpdb.org/pdb/2Q6B>
<https://rdf.wwpdb.org/pdb/2Q6C>
<https://rdf.wwpdb.org/pdb/2R4F>
<https://rdf.wwpdb.org/pdb/3BGL>
<https://rdf.wwpdb.org/pdb/3CCT>
<https://rdf.wwpdb.org/pdb/3CCW>
<https://rdf.wwpdb.org/pdb/3CCZ>
<https://rdf.wwpdb.org/pdb/3CD0>
<https://rdf.wwpdb.org/pdb/3CD5>
<https://rdf.wwpdb.org/pdb/3CD7>
<https://rdf.wwpdb.org/pdb/3CDA>
<https://rdf.wwpdb.org/pdb/3CDB>
wdt:P10283 "C104950815"
wdt:P129 pravastatin
mevastatin
rosuvastatin
lovastatin
fluvastatin
cerivastatin
atorvastatin
simvastatin
wdt:P18 <http://commons.wikimedia.org/wiki/Special:FilePath/HMGR-1DQ8.png>
wdt:P227 "4161000-3"
wdt:P2888 <http://purl.uniprot.org/uniprot/P04035>
wdt:P31 protein
wdt:P352 "P04035"
wdt:P361 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
Hydroxymethylglutaryl-CoA reductase, N-terminal
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
Hydroxymethylglutaryl-CoA reductase, metazoan
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
Eukaryotic Sterol Transporter
Sterol-sensing domain, protein family
Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family
wdt:P373 "HMG-CoA reductase"
wdt:P527 Sterol-sensing domain
Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
wdt:P591 "1.1.1.34"
wdt:P6366 "104950815"
wdt:P637 "NP_000850"
"NP_001124468"
"NP_001351116"
"XP_011541659"
"XP_011541660"
"XP_011541661"
wdt:P638 "1DQ8"
"1DQ9"
"1DQA"
"1HW8"
"1HW9"
"1HWI"
"1HWJ"
"1HWK"
"1HWL"
"2Q1L"
"2Q6B"
"2Q6C"
"2R4F"
"3BGL"
"3CCT"
"3CCW"
"3CCZ"
"3CD0"
"3CD5"
"3CD7"
"3CDA"
"3CDB"
wdt:P646 "/m/03jm8v"
wdt:P680 oxidoreductase activity
NADP binding
protein homodimerization activity
protein phosphatase 2A binding
hydroxymethylglutaryl-CoA reductase (NADPH) activity
NADPH binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein binding
wdt:P681 integral component of membrane
endoplasmic reticulum membrane
membrane
intracellular membrane-bounded organelle
peroxisomal membrane
endoplasmic reticulum
wdt:P682 steroid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
negative regulation of apoptotic process
cholesterol metabolic process
sterol biosynthetic process
positive regulation of cell population proliferation
negative regulation of protein catabolic process
negative regulation of protein secretion
protein tetramerization
positive regulation of cardiac muscle cell apoptotic process
response to ethanol
positive regulation of ERK1 and ERK2 cascade
myoblast differentiation
positive regulation of skeletal muscle tissue development
response to nutrient
positive regulation of smooth muscle cell proliferation
negative regulation of MAP kinase activity
ubiquinone metabolic process
isoprenoid biosynthetic process
negative regulation of striated muscle cell apoptotic process
coenzyme A metabolic process
positive regulation of stress-activated MAPK cascade
negative regulation of wound healing
negative regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of cholesterol biosynthetic process
regulation of lipid metabolic process
negative regulation of amyloid-beta clearance
lipid metabolism
ageing
visual learning
wdt:P692 <http://commons.wikimedia.org/wiki/Special:FilePath/PBB%20GE%20HMGCR%20202539%20s%20at%20fs.png>
wdt:P702 HMGCR
wdt:P703 man
wdt:P705 "ENSP00000287936"
"ENSP00000340816"
"ENSP00000409100"
"ENSP00000420871"
"ENSP00000421378"
"ENSP00000426745"
"ENSP00000427340"
wdt:P7260 "2.A.6.6.5"
Download as:
TurtleJSON-LDRDF/XML
data from SPARQL profile: Wikidata