SHMARQL

dihydrofolate reductase

<http://www.wikidata.org/entity/Q417149>

mammalian protein found in Homo sapiens
dihydrofolate reductase
rdfs:label
"dihydrofolate reductase"@en
skos:altLabel
"DHFR"@en
"uniprot:P00374"@en
schema:description
"mammalian protein found in Homo sapiens"@en
schema:dateModified "2026-10-06T19:09:21+00:00"^^xsd:dateTime
schema:version 2554103020
wikibase:identifiers 79
wikibase:sitelinks 19
wikibase:statements 128
p:P10283 wd:statement/Q417149-AF2AB04F-A643-4ED8-99E0-7DB16BA0E60F
p:P129 wd:statement/Q417149-3D5EED6D-E6C0-4403-A857-87C65D4B4078
wd:statement/Q417149-6107A1DD-06F5-4357-8058-E25C5847938E
wd:statement/Q417149-6B2808B3-A4FC-4B60-8A12-68219C7F38A1
wd:statement/Q417149-801B0FC9-5C8D-4172-9588-0ADA3364DA2C
wd:statement/Q417149-E9FFC782-0B36-4D84-9846-9D76AD0DCC14
p:P18 wd:statement/Q417149-248b843a-4b0a-b9fb-5c13-3f1ffc695807
p:P231 wd:statement/Q417149-fa3c69fd-496d-2267-6ca5-52a628771eb5
p:P2888 wd:statement/Q417149-3D91751A-1CC7-4F5B-95BC-CB1D9547A6DF
p:P31 wd:statement/Q417149-79745C24-CFD4-4A60-860E-29B0D3947367
p:P3417 wd:statement/Q417149-5FDFD503-A2F7-4D9E-84F9-7953CFB614AC
p:P352 wd:statement/q417149-31A13887-982C-403E-904F-46BD6DF6AD7C
p:P361 wd:statement/Q417149-11AC2D35-F098-4EF5-8204-822986D42263
wd:statement/Q417149-7D21276D-CED3-4AD8-8252-DE5F1AE01A52
wd:statement/Q417149-CB70695C-E5D8-441D-B9E4-AC0BF476E946
p:P527 wd:statement/Q417149-8AE32B9A-5E51-48F1-AE0B-ACD76CB797D5
wd:statement/Q417149-DE9F951D-E091-42DB-AAF2-A99505A2C936
p:P591 wd:statement/Q417149-499c9f72-4a5b-b6cc-3ade-002573268db3
wd:statement/Q417149-9d0fafd2-48b7-c6b9-6314-4c2b09523dc6
p:P6366 wd:statement/Q417149-8B50D6BE-803A-4514-926A-1B2EDA9CB3F7
wd:statement/Q417149-A81F941A-8A3E-490A-9114-D61D67CC2D26
p:P637 wd:statement/Q417149-05AE1280-170C-4176-A4ED-892E91435EEE
wd:statement/Q417149-05D649D1-74B4-4FE6-B6DA-439497FAA843
wd:statement/Q417149-3C14EC6F-1853-4E2F-AD1F-E67F179E9E4B
p:P638 wd:statement/Q417149-0E120E0C-9C20-48CD-89A5-A848BF4BAA6A
wd:statement/Q417149-11EC77CE-6AA8-4BB8-9FFD-8BE3CBD604A0
wd:statement/Q417149-30A1DDA0-3098-4032-98CA-BDE2206E88EB
wd:statement/Q417149-45533148-DB52-40FB-B4B8-9CB400166725
wd:statement/Q417149-5F226424-8B5F-41ED-A5EE-70364AB607D4
wd:statement/Q417149-7D489AA5-5EC9-4523-9214-672CF4F8DB05
wd:statement/Q417149-B1DFC7BF-4874-461E-B596-7989CD5CEE4E
wd:statement/Q417149-C9824E65-610C-406F-8FD2-AFBD0570A16F
wd:statement/Q417149-DD80EE97-394D-45CA-BE31-9AC6B1811F19
wd:statement/Q417149-E2BECB13-B7CC-44C4-9439-C186C2E6618B
wd:statement/Q417149-E75DB789-553C-4601-BE0C-E21208DDF0A4
wd:statement/q417149-03B13CD2-AF29-4366-A5B0-C23990D574F1
wd:statement/q417149-0438C537-0A7A-453C-8A1E-56FD473E6CFF
wd:statement/q417149-06117137-3561-4FF7-9149-45DA4280F2E9
wd:statement/q417149-0CE941A8-99CF-44B1-A532-C411A56BA624
wd:statement/q417149-0E53DBD3-3AED-4B54-B5D6-E25EB6E3CC80
wd:statement/q417149-105A9579-E88F-4A4C-8918-DA1092B8B176
wd:statement/q417149-12708D38-1481-4FB4-AA46-83E253328203
wd:statement/q417149-17101046-CFA5-4DB5-AFB3-D917F7B1C2DD
wd:statement/q417149-1EC54DBB-4329-4E92-A315-6F1FF5C2B760
wd:statement/q417149-216C3C66-3163-4BE9-9BF5-654A00D8EBE3
wd:statement/q417149-287D1829-58E0-4DF3-93EA-46178A59BA17
wd:statement/q417149-2925F7D9-25FE-4C0B-ADFD-80A1ECA81BC9
wd:statement/q417149-2A516640-14B8-4710-8CA6-554D9EFAE4C3
wd:statement/q417149-3347B5B5-4626-4117-9685-796D0FC55801
wd:statement/q417149-3770064F-14F7-43BD-B25C-FB07F6091A26
wd:statement/q417149-3C6F0A13-1033-446A-8712-836FE843873B
wd:statement/q417149-3EF9FB2F-EC8F-4541-A387-C44EEB958F38
wd:statement/q417149-4403AC7E-57E6-410D-A681-A85C76FA5717
wd:statement/q417149-477AAD8E-1565-4493-AF6B-169978F45B65
wd:statement/q417149-53333F39-32CD-4B73-8BFA-040DE8E8437D
wd:statement/q417149-57A30AA1-BBA3-4AEB-B774-7976380D0DF2
wd:statement/q417149-5C4D4755-4108-4BA4-A0EC-C017D2933E81
wd:statement/q417149-62E543F0-E6A2-4737-AC96-FC88D9F23C8B
wd:statement/q417149-677503C1-3C5A-406A-B23D-2AE5588285F7
wd:statement/q417149-680AC380-0878-4D5D-A3E0-735F2D95F328
wd:statement/q417149-6F3A314C-9D97-4492-A85A-8945DB703B5A
wd:statement/q417149-73ECB3A4-3662-4AC7-AD15-FA3E339714BA
wd:statement/q417149-775F31A5-873A-444E-B39E-D53D472DF15C
wd:statement/q417149-78EFC520-77A4-432E-B6CF-7E4A951A7959
wd:statement/q417149-7903379A-0589-4C54-919D-975F02B51CE6
wd:statement/q417149-7BD81637-19D4-4A7D-BFD2-6ED1BFF8C113
wd:statement/q417149-7FAD22F0-A8D2-4A2D-ABAC-B5519B349FE6
wd:statement/q417149-8B1E418A-4758-4511-A879-1D8C24E1BF0E
wd:statement/q417149-8B842E3F-7B56-44D1-9CFA-7DF4001843C3
wd:statement/q417149-9F072C63-AD70-405A-AC48-27EAA29DE71F
wd:statement/q417149-A00FCFF7-530B-4A9D-AED8-F57478264FE6
wd:statement/q417149-AD5F78B0-6966-44E9-8380-A43D52556606
wd:statement/q417149-BCAA183B-06A9-4C07-984F-3E9F1A8E3053
wd:statement/q417149-BCE35BE7-4D6C-4151-A8AB-CE3D4759DBE1
wd:statement/q417149-BE3E6D52-5735-4950-A918-2553DB2A77FC
wd:statement/q417149-C71F0A69-02FF-4D99-880D-AA97C7E5C993
wd:statement/q417149-D0435743-59F1-4DB7-8082-DF644C83AD62
wd:statement/q417149-D0B708B3-665D-45F7-ACFE-F23EFEB8044B
wd:statement/q417149-D62F0267-FF98-47EA-95FC-D87613DCD489
wd:statement/q417149-D6B4D2DE-B392-4330-B5A8-994F90933133
wd:statement/q417149-DB56AE03-9101-48DD-B05C-F9CDB7DC8597
wd:statement/q417149-E0C8CED6-BDBC-4451-81F8-D05E1C588382
wd:statement/q417149-E6FE432A-4E98-4441-BD16-78016FD97A90
wd:statement/q417149-E77B21D4-FA9C-4038-8EA0-515DCA970BB5
wd:statement/q417149-EBBDF981-5E42-46DC-A67B-477211614EEC
wd:statement/q417149-F22DD86E-90BD-4563-9C08-3777A21BE4D1
wd:statement/q417149-F919F635-8735-4E6F-AC9F-C07C64B103FE
wd:statement/q417149-FA62B26E-BA74-42AA-B20A-89A0972D4296
wd:statement/q417149-FBB32E8E-91E1-42B6-856E-A722154B79D5
p:P646 wd:statement/Q417149-9CF123C4-EED9-4B72-8AD4-F8D36892F26C
p:P680 wd:statement/Q417149-27D6F93C-7F5C-426D-A3E2-F2188654748C
wd:statement/Q417149-28FEBC82-6744-4342-A712-F341AB8A8901
wd:statement/Q417149-3FC3DA9B-1F0C-435F-A0F4-0C614FD8A9F2
wd:statement/Q417149-404413FF-3983-4FCD-A532-839578F6F8FD
wd:statement/Q417149-4611E140-6EA8-4E22-82AC-EF7FE3B3F434
wd:statement/Q417149-50D3E369-A6B5-40D8-A015-DC15933346A4
wd:statement/Q417149-581BC871-9E62-4290-8E0E-0ED12D51971F
wd:statement/Q417149-6896AA3C-12C4-4859-88AB-14875D192890
wd:statement/Q417149-772D1B80-E3E1-4571-9052-E46766D1F0F5
wd:statement/Q417149-C9E1C39E-56FF-461A-B85F-B47DC87CCA31
wd:statement/Q417149-E53FE3F9-56F8-4239-B0DE-FBC7B2B2BCDA
wd:statement/Q417149-ECC9E310-8307-49DA-B81E-77B07D8208DD
p:P681 wd:statement/Q417149-56C13729-2A5A-406E-A301-992B1177568E
wd:statement/Q417149-8148EDF4-3C0E-4FD7-9A57-0C4E2BC3C272
wd:statement/Q417149-CF767B43-F5F9-4336-93BE-AF000B1C0830
wd:statement/Q417149-E4B25D82-3EEE-446C-AE93-7C99772907C1
wd:statement/Q417149-EE67173D-5B59-474C-98F4-1C0D4B2FD123
p:P682 wd:statement/Q417149-09279B39-1714-46AE-BF38-28A0039EC3C8
wd:statement/Q417149-138BE8D5-3D19-4CC6-8ADC-130E59FC67DE
wd:statement/Q417149-1ADC6C56-F6C1-402B-B319-0CA0FFB3D20E
wd:statement/Q417149-2C76F385-49E4-4C8A-AC48-FD9D1ADDE166
wd:statement/Q417149-3761B1DC-DA5F-4C74-A032-53812A8235F0
wd:statement/Q417149-57636C2C-A931-42B1-9478-91229DE3EB57
wd:statement/Q417149-5DB905A3-0B42-4105-BED6-4500E4008FB3
wd:statement/Q417149-5EF6CF28-0BE1-43DB-9DCF-779BDC6CCCBD
wd:statement/Q417149-75D44FB1-62EA-4249-9100-6F5B2512102A
wd:statement/Q417149-9295BC15-0122-43AD-B0F5-DE5D160CD1E9
wd:statement/Q417149-C42D0151-36CC-419B-8C4F-B4ADD398D97B
wd:statement/Q417149-C82B5F32-416F-40E1-87BE-70F15C315142
wd:statement/Q417149-DEE513F4-04C4-421C-B04E-A4210C231EB5
wd:statement/Q417149-E45BEB8A-8946-4B79-A205-A3F7E32CE66D
wd:statement/Q417149-FD314C81-8A12-4C97-B2EE-29172775ECCF
p:P702 wd:statement/q417149-707D8462-5840-497B-8AC2-2701110C0FE7
p:P703 wd:statement/Q417149-568DBC13-3686-4C20-B549-919DB7F3AD00
p:P705 wd:statement/Q417149-BAE8AB11-79A1-40E8-8CCA-4D695CFB0B68
wd:statement/q417149-42ED84EC-E392-4B7D-B5CC-8DAB71D48D06
wd:statement/q417149-ED85646E-7102-4207-92FE-CE702DA87147
wd:statement/q417149-F915FD73-07B8-4C99-8334-493D559D9A59
p:direct-normalized/P352 <http://purl.uniprot.org/uniprot/P00374>
p:direct-normalized/P6366 <https://makg.org/entity/2781320022>
<https://makg.org/entity/2909764806>
p:direct-normalized/P637 <http://purl.uniprot.org/refseq/NP_000782>
<http://purl.uniprot.org/refseq/NP_001277283>
<http://purl.uniprot.org/refseq/NP_001277286>
p:direct-normalized/P638 <https://rdf.wwpdb.org/pdb/1BOZ>
<https://rdf.wwpdb.org/pdb/1DHF>
<https://rdf.wwpdb.org/pdb/1DLR>
<https://rdf.wwpdb.org/pdb/1DLS>
<https://rdf.wwpdb.org/pdb/1DRF>
<https://rdf.wwpdb.org/pdb/1HFP>
<https://rdf.wwpdb.org/pdb/1HFQ>
<https://rdf.wwpdb.org/pdb/1HFR>
<https://rdf.wwpdb.org/pdb/1KMS>
<https://rdf.wwpdb.org/pdb/1KMV>
<https://rdf.wwpdb.org/pdb/1MVS>
<https://rdf.wwpdb.org/pdb/1MVT>
<https://rdf.wwpdb.org/pdb/1OHJ>
<https://rdf.wwpdb.org/pdb/1OHK>
<https://rdf.wwpdb.org/pdb/1PD8>
<https://rdf.wwpdb.org/pdb/1PD9>
<https://rdf.wwpdb.org/pdb/1PDB>
<https://rdf.wwpdb.org/pdb/1S3U>
<https://rdf.wwpdb.org/pdb/1S3V>
<https://rdf.wwpdb.org/pdb/1S3W>
<https://rdf.wwpdb.org/pdb/1U71>
<https://rdf.wwpdb.org/pdb/1U72>
<https://rdf.wwpdb.org/pdb/1YHO>
<https://rdf.wwpdb.org/pdb/2C2S>
<https://rdf.wwpdb.org/pdb/2C2T>
<https://rdf.wwpdb.org/pdb/2DHF>
<https://rdf.wwpdb.org/pdb/2W3A>
<https://rdf.wwpdb.org/pdb/2W3B>
<https://rdf.wwpdb.org/pdb/2W3M>
<https://rdf.wwpdb.org/pdb/3EIG>
<https://rdf.wwpdb.org/pdb/3F8Y>
<https://rdf.wwpdb.org/pdb/3F8Z>
<https://rdf.wwpdb.org/pdb/3F91>
<https://rdf.wwpdb.org/pdb/3FS6>
<https://rdf.wwpdb.org/pdb/3GHC>
<https://rdf.wwpdb.org/pdb/3GHV>
<https://rdf.wwpdb.org/pdb/3GHW>
<https://rdf.wwpdb.org/pdb/3GI2>
<https://rdf.wwpdb.org/pdb/3GYF>
<https://rdf.wwpdb.org/pdb/3L3R>
<https://rdf.wwpdb.org/pdb/3N0H>
<https://rdf.wwpdb.org/pdb/3NTZ>
<https://rdf.wwpdb.org/pdb/3NU0>
<https://rdf.wwpdb.org/pdb/3NXO>
<https://rdf.wwpdb.org/pdb/3NXR>
<https://rdf.wwpdb.org/pdb/3NXT>
<https://rdf.wwpdb.org/pdb/3NXV>
<https://rdf.wwpdb.org/pdb/3NXX>
<https://rdf.wwpdb.org/pdb/3NXY>
<https://rdf.wwpdb.org/pdb/3NZD>
<https://rdf.wwpdb.org/pdb/3OAF>
<https://rdf.wwpdb.org/pdb/3S3V>
<https://rdf.wwpdb.org/pdb/3S7A>
<https://rdf.wwpdb.org/pdb/4DDR>
<https://rdf.wwpdb.org/pdb/4G95>
<https://rdf.wwpdb.org/pdb/4KAK>
<https://rdf.wwpdb.org/pdb/4KBN>
<https://rdf.wwpdb.org/pdb/4KD7>
<https://rdf.wwpdb.org/pdb/4KEB>
<https://rdf.wwpdb.org/pdb/4KFJ>
<https://rdf.wwpdb.org/pdb/4M6J>
<https://rdf.wwpdb.org/pdb/4M6K>
<https://rdf.wwpdb.org/pdb/4M6L>
<https://rdf.wwpdb.org/pdb/4QHV>
<https://rdf.wwpdb.org/pdb/4QJC>
wdt:P10283 "C2781320022"
wdt:P129 trimetrexate
piritrexim
pemetrexed
methotrexate
pralatrexate
wdt:P18 <http://commons.wikimedia.org/wiki/Special:FilePath/PDB%208dfr%20EBI.jpg>
wdt:P231 "9002-03-3"
wdt:P2888 <http://purl.uniprot.org/uniprot/P00374>
wdt:P31 protein
wdt:P3417 "Dhfr"
wdt:P352 "P00374"
wdt:P361 Dihydrofolate reductase-like domain superfamily
Dihydrofolate reductase domain, protein family
Dihydrofolate reductase conserved site, protein family
wdt:P527 Dihydrofolate reductase domain
Dihydrofolate reductase conserved site
wdt:P591 "1.5.1.3"
wdt:P6366 "2781320022"
"2909764806"
wdt:P637 "NP_000782"
"NP_001277283"
"NP_001277286"
wdt:P638 "1BOZ"
"1DHF"
"1DLR"
"1DLS"
"1DRF"
"1HFP"
"1HFQ"
"1HFR"
"1KMS"
"1KMV"
"1MVS"
"1MVT"
"1OHJ"
"1OHK"
"1PD8"
"1PD9"
"1PDB"
"1S3U"
"1S3V"
"1S3W"
"1U71"
"1U72"
"1YHO"
"2C2S"
"2C2T"
"2DHF"
"2W3A"
"2W3B"
"2W3M"
"3EIG"
"3F8Y"
"3F8Z"
"3F91"
"3FS6"
"3GHC"
"3GHV"
"3GHW"
"3GI2"
"3GYF"
"3L3R"
"3N0H"
"3NTZ"
"3NU0"
"3NXO"
"3NXR"
"3NXT"
"3NXV"
"3NXX"
"3NXY"
"3NZD"
"3OAF"
"3S3V"
"3S7A"
"4DDR"
"4G95"
"4KAK"
"4KBN"
"4KD7"
"4KEB"
"4KFJ"
"4M6J"
"4M6K"
"4M6L"
"4QHV"
"4QJC"
wdt:P646 "/m/0pys4"
wdt:P680 RNA binding
oxidoreductase activity
NADP binding
mRNA binding
dihydrofolate reductase activity
NADPH binding
folic acid binding
methotrexate binding
translation repressor activity, mRNA regulatory element binding
sequence-specific mRNA binding
folate reductase activity
wdt:P681 cytosol
mitochondrion
cellular component
cytoplasm
wdt:P682 negative regulation of translation
positive regulation of nitric-oxide synthase activity
one-carbon metabolic process
response to methotrexate
dihydrofolate metabolic process
tetrahydrofolate metabolic process
tetrahydrofolate biosynthetic process
axon regeneration
regulation of removal of superoxide radicals
folic acid metabolic process
tetrahydrobiopterin biosynthetic process
regulation of transcription involved in G1/S transition of mitotic cell cycle
wdt:P702 DHFR
wdt:P703 man
wdt:P705 "ENSP00000396308"
"ENSP00000421334"
"ENSP00000422732"
"ENSP00000426474"
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data from SPARQL profile: Wikidata