SHMARQL

cystic fibrosis transmembrane conductance regulator

<http://www.wikidata.org/entity/Q420470>

mammalian protein found in Homo sapiens
rdfs:label
"cystic fibrosis transmembrane conductance regulator"@en
skos:altLabel
"3.6.3.49"@en
"ATP-binding cassette sub-family C member 7"@en
"CFTR"@en
"cAMP-dependent chloride channel"@en
"channel conductance-controlling ATPase"@en
"cystic fibrosis transmembrane conductance regulating"@en
"cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)"@en
schema:description
"mammalian protein found in Homo sapiens"@en
schema:dateModified "2026-10-04T19:18:47+00:00"^^xsd:dateTime
schema:version 2553155804
wikibase:identifiers 30
wikibase:sitelinks 23
wikibase:statements 129
p:P10283 wd:statement/Q420470-66A02888-B101-4E7C-9BBE-EF7D97673753
wd:statement/Q420470-A3FEC905-B259-483F-A26B-4993B4288126
p:P129 wd:statement/Q420470-639533E8-5559-4813-95B5-C8EEB9FCAF0A
wd:statement/Q420470-83CDF848-7C0A-4E72-80BE-CFBDF5F30E46
wd:statement/Q420470-8DE3EFAD-7E7B-424F-9E0E-0D4966B43DB4
wd:statement/Q420470-92ABD660-965A-44F2-AEA7-7C0DE7CD9371
wd:statement/Q420470-A7248950-6443-4F2B-879F-9D78190ABE74
wd:statement/Q420470-B6A26F16-B89C-4C2F-8CF5-6AF3BFC69863
wd:statement/Q420470-C618E6DE-DA6B-4A02-8E70-2A53657FD4E5
p:P2888 wd:statement/Q420470-0AF52459-6FA7-4680-9F98-90A653171070
p:P31 wd:statement/Q420470-85304841-EDA2-44E7-90D0-4CF71D134978
p:P352 wd:statement/q420470-431B5DC8-CD53-4DCE-B510-8BCB82A55E70
p:P354 wd:statement/Q420470-a6b1c7b2-4d5f-55bd-56aa-f522a52b106a
p:P361 wd:statement/Q420470-0CDA3C78-31CA-43D6-BBFB-B832307E235E
wd:statement/Q420470-6309ABD1-12E5-4397-A2E2-CD73FCB62FB7
wd:statement/Q420470-6463AD1A-F261-485E-92D4-F4B6F381FFAE
wd:statement/Q420470-857510A8-93D9-4B49-A39C-A31D24B1466A
wd:statement/Q420470-AB5C78BC-8205-4355-B9BD-1CE3A23FCD6E
wd:statement/Q420470-BA98497B-086B-4787-B7E7-0A8927001D3D
wd:statement/Q420470-CEF8CFD0-6E62-4D33-BF02-9FF4C73BF60D
wd:statement/Q420470-DF590288-41C5-479D-B218-F9E4E4079D74
p:P373 wd:statement/Q420470-976e7eb7-1685-4c1c-a7f5-8b53845287d7
p:P492 wd:statement/Q420470-ac705013-466f-bad3-cfdc-7ab17f9838cb
p:P527 wd:statement/Q420470-1DADEDC0-5729-4E55-92D1-DE2DCD00940E
wd:statement/Q420470-3BC4DCB4-B604-4ECF-BA8F-4AE011439A0D
wd:statement/Q420470-5407C301-58B5-40F6-848C-3F0C55317015
wd:statement/Q420470-97D44B27-32C6-42BB-B03C-A68B5A224948
wd:statement/Q420470-9B84FD4F-5FE2-4B7D-9DAA-EB0C2D28A6D8
p:P591 wd:statement/Q420470-50753923-7421-4935-8FEB-49AB682595A1
p:P6366 wd:statement/Q420470-0B1C5924-AB84-4C4B-B2B0-7D38DD02CF0F
wd:statement/Q420470-E2DB9955-E001-4130-B450-34F75D91BD40
p:P637 wd:statement/Q420470-A21B671E-69FE-4135-A823-777E6D88DE05
p:P638 wd:statement/Q420470-060FD2ED-FA3E-45FD-917B-F9CF36657E63
wd:statement/Q420470-1AD410F3-39DE-4B69-B619-17DA95DAEA30
wd:statement/Q420470-37BDDB50-27B7-4E42-98D6-C2000F3BAC2C
wd:statement/Q420470-8EF761A8-D0C0-43B6-B65A-18F9609B4ECE
wd:statement/q420470-0F9BF647-C240-463E-B714-2E189725C69F
wd:statement/q420470-2552D56D-8C31-4D43-A649-81BDD3BA0445
wd:statement/q420470-304DF7FF-BA14-4DA5-BC28-3CCFDFDB5C33
wd:statement/q420470-44CEED1E-C899-4805-9A7D-C744E466ED7C
wd:statement/q420470-4A9D6E9F-35A5-430A-B836-71242D0CD072
wd:statement/q420470-4C0C691E-E528-4AF4-A1CF-0DDF8E745870
wd:statement/q420470-7FFE77D8-10C5-4419-ABD2-48142A03E753
wd:statement/q420470-86ABD46A-9C6D-4DE2-B007-652656BCD4E2
wd:statement/q420470-AF89B016-3D74-4568-9454-78A2B07460BE
wd:statement/q420470-BA91C1F2-60B7-4699-83AB-7FDB8473DED1
wd:statement/q420470-D69D0A9D-41C9-49A8-BA67-1895ED6CC624
p:P646 wd:statement/Q420470-78A44D5E-E91B-4637-BC64-E10056249A2B
p:P680 wd:statement/Q420470-01229C3C-DDD4-49F4-BCC5-4909D75F30BA
wd:statement/Q420470-0BC22B92-9B31-4C97-A02A-423D84750FFC
wd:statement/Q420470-1A064D7C-6A06-4D17-AF95-B4AA7D5FDE69
wd:statement/Q420470-1E9E8C85-27AD-4E47-9497-F4A7E5C7AE79
wd:statement/Q420470-2967BE45-3EB1-49FD-B476-13523F38DEE7
wd:statement/Q420470-72D8DAB8-5F70-4515-AF65-580CBE9884CE
wd:statement/Q420470-97A9E39D-8357-401D-8AD5-62900B177FAE
wd:statement/Q420470-9A530C14-ABAB-4036-80ED-AC981F009475
wd:statement/Q420470-9ABD0AF0-EFE4-4C8C-A564-30640289355E
wd:statement/Q420470-9F9CD734-E191-4D77-8390-7816251CBD9C
wd:statement/Q420470-AE2E04F6-B355-49F1-9ED1-D06D50BF2136
wd:statement/Q420470-B37FC422-F3CE-43AE-A266-32BFB974E5A7
wd:statement/Q420470-B8E0804B-F70C-4321-8608-E3664FBF5EA4
wd:statement/Q420470-D0AA363B-4DFC-4F72-978D-690A6482ADB7
wd:statement/Q420470-D6B80F34-D9AF-400F-BD1E-EE9D430EF13A
wd:statement/Q420470-DA141C71-B39E-45E4-A0C1-9C0B44E4113D
wd:statement/Q420470-E326C6DF-213F-45B8-8789-708EF08B1D90
wd:statement/Q420470-EA2047BB-7E03-4FA8-BC74-486AC750632E
wd:statement/Q420470-FBD06FC4-9213-49F8-82EB-67332E40CF4A
p:P681 wd:statement/Q420470-04B05545-C4D2-41BC-9B00-E79ADABA36F6
wd:statement/Q420470-0D8AB655-8B7B-49E9-BA46-E70F5F720C18
wd:statement/Q420470-19E14660-6A9B-4EC1-832B-BFCBEB5280EE
wd:statement/Q420470-1F1C47A6-D9C2-49DF-ACE2-B6F8954B1570
wd:statement/Q420470-3A38275C-5C3C-4DDD-9116-21B5F147697D
wd:statement/Q420470-3A778BF3-80D0-439B-BC8E-AC7D9657E007
wd:statement/Q420470-3AF90DAF-E108-4E27-8E5C-ADE5D13E58F4
wd:statement/Q420470-3BDFCF51-2100-4D33-AA21-19342F66B727
wd:statement/Q420470-3C4AB3A6-196F-4184-8F17-E42384504A7E
wd:statement/Q420470-46B8FB65-4071-4E69-BA54-B389E12FF9F4
wd:statement/Q420470-524BA191-9BC4-4FAB-84CA-77DD32705BE2
wd:statement/Q420470-5587619A-F244-4CC9-BD1D-BF01BA1E9133
wd:statement/Q420470-5A96ED32-92F1-458D-A712-0F6A4DA6AB01
wd:statement/Q420470-5B38FFA9-1E98-40DA-919F-B29854E888CA
wd:statement/Q420470-74F41074-CAC6-4478-810F-A3322FABEE45
wd:statement/Q420470-77D123DA-0132-45F2-B988-B6A96A4C1CDD
wd:statement/Q420470-7C8C999D-ABCB-401E-B5DF-E28386E77CFA
wd:statement/Q420470-8E60BD7B-8864-4D1B-BF20-D2BF50DDCD94
wd:statement/Q420470-97CFF63F-DB05-4A0C-932D-D2A9B76AE279
wd:statement/Q420470-9AC8BEBC-3F31-4E05-AC97-9C38D0FCD3AE
wd:statement/Q420470-A591C650-23CF-45C4-983D-B5B3D3E3BA6E
wd:statement/Q420470-A780A3E6-C38E-4FBB-A8A2-4E97D99C8E3C
wd:statement/Q420470-AC134C01-706F-4906-83FF-DEE18D77EF57
wd:statement/Q420470-ADFDB3FF-3A9D-40BB-85F9-03E8142B52F5
wd:statement/Q420470-AFEB917A-AE2C-4465-AC6F-6E4820B91AB5
wd:statement/Q420470-B946B62D-BA8A-473F-B8A9-5BE21DD3AF61
wd:statement/Q420470-F39328FE-7F7D-45DA-B2FF-018BF84BB364
wd:statement/Q420470-FC77E3CA-6E35-4C40-816C-5E2CD2405EBB
p:P682 wd:statement/Q420470-0A1D2B06-876D-45EA-B887-5202DBC6B5E9
wd:statement/Q420470-1562C51D-1319-452A-8EC0-77F49C92A86E
wd:statement/Q420470-2792E0EC-B27B-4FCE-8822-B907A444B147
wd:statement/Q420470-2A2DD048-F152-429F-B551-452BFF0A0E11
wd:statement/Q420470-3D70A335-FC99-4292-9DD6-4890F4ADD734
wd:statement/Q420470-44F44C52-5F0D-476F-9B69-85D4A6DE1200
wd:statement/Q420470-4772D85F-6DD4-46ED-A028-835BA36D074A
wd:statement/Q420470-48E83B75-1664-49A0-BAA7-12A83DBCFB9D
wd:statement/Q420470-4FD09311-A6F1-4EF0-A72F-561409F466E0
wd:statement/Q420470-65B30771-C1D7-4C54-AE15-3701731FE822
wd:statement/Q420470-7EBA5320-05DD-4683-820B-C7393CDFA34E
wd:statement/Q420470-8E497C21-89D6-4FF1-90FB-9D4133160460
wd:statement/Q420470-99DF7596-CA4A-4C75-8CCB-5FBF485C5784
wd:statement/Q420470-9BB4872E-61F1-419F-B8A5-B6E2F796D2C2
wd:statement/Q420470-9F10AC4A-13B8-4260-AE95-C5534162C581
wd:statement/Q420470-ACC10441-37D5-4283-9742-736DE35DF1C3
wd:statement/Q420470-B4BB84A3-9EF9-4925-8EE5-0A1E01C2485F
wd:statement/Q420470-B551E4AA-D922-496D-8835-FA9ADB0514CB
wd:statement/Q420470-BECA6ADE-EB2F-46C0-B085-4E7973B9C9AA
wd:statement/Q420470-BFDD4C69-253D-4674-B258-0F3A4E962B1D
wd:statement/Q420470-C87CD8E0-8615-4B7F-9DF9-BE711550D614
wd:statement/Q420470-D165DB15-FF54-4786-B74D-6182924CBA3B
wd:statement/Q420470-D67EB206-E200-48E9-AF7D-48EED17B33F6
wd:statement/Q420470-E9208FE5-ABDA-435E-905C-F71534A6B235
wd:statement/Q420470-EB884EB6-4553-4DC8-983C-BA2479ED8CCA
wd:statement/Q420470-EC17722C-E390-46AD-9576-EEC6F2013015
p:P702 wd:statement/q420470-0606AEF8-8C3A-42D4-BF33-12058291DDE3
p:P703 wd:statement/Q420470-8A03C501-5F59-4D8C-A015-10B7F873F4E2
p:P705 wd:statement/Q420470-1362CE64-966D-4229-AD8A-0667C43225EC
wd:statement/Q420470-297A7530-82EA-4D47-ABDD-6D4EBC00F676
wd:statement/Q420470-749CE852-81AD-4618-B4CC-275B1EA34FC0
wd:statement/Q420470-E1EE4260-5264-475C-AD02-C5D2D69D2E55
wd:statement/q420470-87CF2D35-97F5-4746-BB23-2B62096552F0
p:P7260 wd:statement/Q420470-7F2F5078-F54F-43CE-9D2E-53A3448B0363
p:direct-normalized/P352 <http://purl.uniprot.org/uniprot/P13569>
p:direct-normalized/P6366 <https://makg.org/entity/2777893369>
<https://makg.org/entity/2778428886>
p:direct-normalized/P637 <http://purl.uniprot.org/refseq/NP_000483>
p:direct-normalized/P638 <https://rdf.wwpdb.org/pdb/1XMI>
<https://rdf.wwpdb.org/pdb/1XMJ>
<https://rdf.wwpdb.org/pdb/2BBO>
<https://rdf.wwpdb.org/pdb/2BBS>
<https://rdf.wwpdb.org/pdb/2BBT>
<https://rdf.wwpdb.org/pdb/2LOB>
<https://rdf.wwpdb.org/pdb/2PZE>
<https://rdf.wwpdb.org/pdb/2PZF>
<https://rdf.wwpdb.org/pdb/2PZG>
<https://rdf.wwpdb.org/pdb/3GD7>
<https://rdf.wwpdb.org/pdb/3ISW>
<https://rdf.wwpdb.org/pdb/4WZ6>
<https://rdf.wwpdb.org/pdb/5D2D>
<https://rdf.wwpdb.org/pdb/5D3E>
<https://rdf.wwpdb.org/pdb/5D3F>
wdt:P10283 "C2777893369"
"C2778428886"
wdt:P129 capsaicin
genistein
glyburide
felodipine
nimodipine
apigenin
ivacaftor
wdt:P2888 <http://purl.uniprot.org/uniprot/P13569>
wdt:P31 protein
wdt:P352 "P13569"
wdt:P354 "1884"
wdt:P361 P-loop containing nucleoside triphosphate hydrolase
cystic fibrosis transmembrane conductance regulator
ABC transporter type 1, transmembrane domain superfamily
AAA proteins
CFTR regulator domain, protein family
ABC transporter type 1, transmembrane domain, protein family
ABC transporter-like, protein family
ABC transporter, conserved site, protein family
wdt:P373 "Cystic fibrosis transmembrane conductance regulator"
wdt:P492 "602421"
wdt:P527 ABC transporter, conserved site
ABC transporter type 1, transmembrane domain
CFTR regulator domain
ABC transporter-like
AAA+ ATPase domain
wdt:P591 "5.6.1.6"
wdt:P6366 "2777893369"
"2778428886"
wdt:P637 "NP_000483"
wdt:P638 "1XMI"
"1XMJ"
"2BBO"
"2BBS"
"2BBT"
"2LOB"
"2PZE"
"2PZF"
"2PZG"
"3GD7"
"3ISW"
"4WZ6"
"5D2D"
"5D3E"
"5D3F"
wdt:P646 "/m/04kgs0"
wdt:P680 hydrolase activity
enzyme binding
chaperone binding
ATP binding
PDZ domain binding
nucleotide binding
ATPase activity
chloride channel activity
intracellularly ATP-gated chloride channel activity
chloride channel inhibitor activity
ATPase-coupled transmembrane transporter activity
isomerase activity
chloride transmembrane transporter activity
chloride channel regulator activity
protein binding
bicarbonate transmembrane transporter activity
ATPase-coupled inorganic anion transmembrane transporter activity
Sec61 translocon complex binding
wdt:P681 integral component of membrane
endoplasmic reticulum membrane
membrane
apical plasma membrane
integral component of plasma membrane
early endosome
endosome membrane
recycling endosome
endoplasmic reticulum Sec complex
early endosome membrane
chloride channel complex
recycling endosome membrane
lysosomal membrane
Golgi-associated vesicle membrane
cell surface
clathrin-coated vesicle membrane
cytosol
protein-containing complex
plasma membrane
nucleus
cytoplasm
endoplasmic reticulum
endosome
extracellular exosome
wdt:P682 transport
cholesterol biosynthetic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus
multicellular organismal water homeostasis
transmembrane transport
ion transport
sperm capacitation
membrane hyperpolarization
cellular response to cAMP
protein deubiquitination
cholesterol transport
bicarbonate transport
chloride transport
response to endoplasmic reticulum stress
membrane organization
transepithelial water transport
positive regulation of exocytosis
chloride transmembrane transport
vesicle docking involved in exocytosis
cellular response to forskolin
intracellular pH elevation
positive regulation of cyclic nucleotide-gated ion channel activity
positive regulation of voltage-gated chloride channel activity
wdt:P702 CFTR
wdt:P703 man
wdt:P705 "ENSP00000003084"
"ENSP00000389119"
"ENSP00000417012"
"ENSP00000419254"
"ENSP00000470177"
wdt:P7260 "3.A.1.202.1"
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data from SPARQL profile: Wikidata