SHMARQL

diltiazem

<http://www.wikidata.org/entity/Q422229>

nondihydropyridine (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia
rdfs:label
"diltiazem"@en
skos:altLabel
"(+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester"@en
"(+)-cis-diltiazem"@en
"(2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate"@en
"(2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one"@en
"CRD-401"@en
"Cardizem®"@en
"D-(cis)-diltiazem"@en
"D-cis-diltiazem"@en
"DILTIAZEM"@en
"Dilacor-XR®"@en
"RG-83606"@en
schema:description
"nondihydropyridine (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia"@en
schema:dateModified "2026-04-23T07:53:41+00:00"^^xsd:dateTime
schema:version 2484086554
wikibase:identifiers 50
wikibase:sitelinks 34
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p:direct-normalized/P2115 <http://purl.bioontology.org/ontology/NDFRT/N0000147814>
p:direct-normalized/P486 <http://id.nlm.nih.gov/mesh/D004110>
p:direct-normalized/P592 <http://rdf.ebi.ac.uk/resource/chembl/molecule/CHEMBL23>
p:direct-normalized/P6366 <https://makg.org/entity/2776741139>
p:direct-normalized/P661 <http://rdf.chemspider.com/35850>
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p:direct-normalized/P683 <http://purl.obolibrary.org/obo/CHEBI_101278>
p:direct-normalized/P8408 <http://kbpedia.org/kko/rc/Diltiazem>
p:direct-normalized/P8814 <http://wordnet-rdf.princeton.edu/rdf/id/03203321-n>
wdt:P10245 "a684027"
wdt:P10283 "C2776741139"
"C2909111407"
wdt:P11089 "117273"
wdt:P11143 "Diltiazem"
wdt:P11198 "897"
wdt:P11199 "PD010090"
wdt:P117 <http://commons.wikimedia.org/wiki/Special:FilePath/Diltiazem%20structure.svg>
wdt:P129 Potassium voltage-gated channel, shaker-related subfamily, member 1
Calcium voltage-gated channel subunit alpha1 C
Potassium voltage-gated channel subfamily A member 5
5-hydroxytryptamine receptor 3A
Calcium voltage-gated channel subunit alpha1 S
Potassium voltage gated channel, Shaw-related subfamily, member 1
Potassium voltage-gated channel, shaker-related subfamily, member 7
5-hydroxytryptamine (serotonin) receptor 3A
Voltage-dependent L-type calcium channel subunit alpha-1F
wdt:P13204 "bsfmx2qn"
wdt:P1417 "science/diltiazem"
wdt:P1579 "3573079"
wdt:P2017 "CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC"
wdt:P2057 "HMDB0014487"
wdt:P2062 "6528"
wdt:P2067 414.161^^xsd:decimal
wdt:P2085 "J16.566B"
wdt:P2115 "N0000147814"
wdt:P2175 myocardial infarction
supraventricular tachycardia
angina pectoris
arterial hypertension
atrial fibrillation
wdt:P2275 "diltiazem"@en
wdt:P231 "42399-41-7"
wdt:P232 "255-796-4"
wdt:P233 "CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC"
wdt:P234 "InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1"
wdt:P235 "HSUGRBWQSSZJOP-RTWAWAEBSA-N"
wdt:P2566 "100.050.707"
wdt:P267 "C05AE03"
"C08DB01"
wdt:P274 "C₂₂H₂₆N₂O₄S"
wdt:P279 heterocyclic compound
calcium channel blocker
wdt:P2868 vasodilator agent
calcium channel blocker
cardiovascular agent
antihypertensive drug
wdt:P2877 "17776"
wdt:P2892 "C0012373"
wdt:P31 type of chemical entity
wdt:P3117 "DTXSID9022940"
wdt:P3345 "3443"
wdt:P3364 L-(cis)-diltiazem
wdt:P3489 US pregnancy category C
wdt:P3636 "C9F"
wdt:P366 medication
wdt:P373 "Diltiazem"
wdt:P3780 Tiadylt
Matzim
Diltzac
Tiazac
Taztia
Dilt
Cardizem
Dilacor
Cartia
wdt:P4250 0.24^^xsd:decimal
wdt:P486 "D004110"
wdt:P4964 "splash10-0ab9-9200000000-b1095b8fe5973d23fdd6"
wdt:P5076 "RD-04-01636"
wdt:P527 carbon
nitrogen
sulfur
wdt:P592 "CHEMBL23"
wdt:P595 "2298"
wdt:P6366 "2776741139"
wdt:P646 "/m/035www"
wdt:P652 "EE92BBP03H"
wdt:P661 "35850"
wdt:P662 "39186"
wdt:P665 "D07845"
wdt:P6689 "MSBNK-Waters-WA000849"
"MSBNK-Waters-WA000851"
"MSBNK-Waters-WA000852"
"MSBNK-Waters-WA000853"
"MSBNK-Waters-WA000854"
wdt:P6694 "M0006434"
wdt:P672 "D03.633.100.079.150"
wdt:P683 "101278"
wdt:P715 "DB00343"
wdt:P769 droperidol
alfentanil
(RS)-methadone
erythromycin
alfuzosin
avanafil
sirolimus
cyclosporine
levobunolol
(RS)-metoprolol
amiodarone
phenytoin
atenolol
clonidine
bisoprolol
carvedilol
bromocriptine
sotalol
pindolol
nebivolol
esmolol
acebutolol
celiprolol
dantrolene
digoxin
ritonavir
propranolol
vardenafil
domperidone
nadolol
fingolimod
ivabradine
crizotinib
fosphenytoin
guanfacine
imipramine
atorvastatin
simvastatin
betaxolol
labetalol
wdt:P7830 "Diltiazem"
wdt:P8026 LiverTox toxicity likelihood category C
wdt:P8408 "Diltiazem"
wdt:P8494 "DTXCID202940"
wdt:P8814 "03203321-n"
wdt:P9989 "dilTIAZem"
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