cellular communication network factor 2

mammalian protein found in Homo sapiens
rdfs:label
"cellular communication network factor 2"@en
skos:altLabel "CCN family member 2"@en
"CCN2"@en
"CTGF"@en
"IBP-8"@en
"IGF-binding protein 8"@en
"IGFBP-8"@en
"connective tissue growth factor"@en
"hypertrophic chondrocyte-specific protein 24"@en
"insulin-like growth factor-binding protein 8"@en
schema:description
"mammalian protein found in Homo sapiens"@en
schema:dateModified "2025-07-23T23:10:24+00:00"^^xsd:dateTime
schema:version 2383341895
wikibase:identifiers 9
wikibase:sitelinks 0
wikibase:statements 95
p:P2888 wd:statement/Q5014566-21C1006A-F570-4A44-B461-7AB453489506
p:P2892 wd:statement/Q5014566-B27E0FF9-F236-4AC4-8335-360823875FC9
p:P31 wd:statement/Q5014566-79D5E015-08F1-4FC2-8733-1C20D8047F18
p:P352 wd:statement/Q5014566-2F27BE07-0EBF-49A9-A40D-0A28C5EE99AE
p:P361 wd:statement/Q5014566-077ED421-97EA-4003-86A8-178F41F7118C
wd:statement/Q5014566-17F5A1C4-F9B4-4440-8B86-E469BA8F3AE2
wd:statement/Q5014566-37182E83-5A12-4260-9C4B-5EFDFB2B62B0
wd:statement/Q5014566-641A36B7-D5EA-4626-8396-8B4BEF79DC5A
wd:statement/Q5014566-74582878-0B9A-49B8-A0E5-9F98D082F852
wd:statement/Q5014566-79D18478-C2B1-461D-9F6A-028A8261D7BE
wd:statement/Q5014566-8CE4F622-ADC9-4FCA-8C02-7F77354F0D07
wd:statement/Q5014566-9133A542-CDCB-4126-870B-8A4B53FE2E30
wd:statement/Q5014566-C7A0BEBB-AF35-46E6-834F-74F42304B60B
p:P486 wd:statement/Q5014566-3D8A6818-4196-47A4-873F-193474C92599
p:P527 wd:statement/Q5014566-08CE835E-22F7-4D43-95A7-20325C84BE71
wd:statement/Q5014566-1D66A8B6-7A80-4632-926B-B4726C4A3FA4
wd:statement/Q5014566-4CA1CDE1-3C02-479B-8F74-95180344FC1B
wd:statement/Q5014566-6712D36E-9DBA-463D-A8F0-2A8376D6FE96
wd:statement/Q5014566-7D7AA060-9E62-4FA5-BBB4-0D8D65A4BBA7
wd:statement/Q5014566-D90CDD33-DC16-4F96-B0AA-D59A1325977B
p:P637 wd:statement/Q5014566-E0B7FC30-DBEF-48C5-9CDD-7FB8CE2272CC
p:P672 wd:statement/Q5014566-1f187436-4409-af74-3fe1-b3ca908fc2e9
wd:statement/Q5014566-436a286d-4d85-6f54-a146-fd456090c379
wd:statement/Q5014566-6edb6b2c-4184-bc0c-82f2-c1b21b7416ba
wd:statement/Q5014566-dbee530f-4c9e-f22d-1ab5-15c634583d85
p:P680 wd:statement/Q5014566-1C083366-4A11-4757-8231-4A2959CB2BAD
wd:statement/Q5014566-4333A7B6-0EB5-4C98-B1C1-2C44FD775F0A
wd:statement/Q5014566-5FE2B43F-1EF5-422E-8F2C-E9A9B361687D
wd:statement/Q5014566-A5983948-7EC5-40EE-BF3A-F75FF27FEC39
wd:statement/Q5014566-D4598F3F-318C-44C1-A14B-2573D164CA76
wd:statement/Q5014566-E49716C1-0BD7-41D9-8006-E6A937A97C5A
wd:statement/Q5014566-E571FBE3-A474-4557-BE45-6202C60F9287
p:P681 wd:statement/Q5014566-21A2655D-17F9-4CBF-86A5-8A3623AE09D9
wd:statement/Q5014566-22F8E598-74FC-48B9-971F-691837AFFE60
wd:statement/Q5014566-47B9F25A-1966-4C8F-AA88-B54366C88144
wd:statement/Q5014566-8B72D1FD-2EA2-4290-911F-093672DAEF8A
wd:statement/Q5014566-A7D84909-08CC-4997-A641-5904D91C2FB1
wd:statement/Q5014566-AEB2217E-AD41-44A6-8BDB-F06CBA2E7509
wd:statement/Q5014566-CB014510-087B-41ED-8A02-EFEFAE678F64
wd:statement/Q5014566-DAC493BB-A1A3-41F7-8979-7B7E6C516D7A
wd:statement/Q5014566-E1DC2DF0-839D-4166-B2C2-F6DBF7EE40EA
wd:statement/Q5014566-E9CB53FE-5E16-4007-8D60-3F874BD0B7C6
wd:statement/Q5014566-FC2342DC-481A-4657-83AD-36B6ED797456
p:P682 wd:statement/Q5014566-129DBD15-FFA1-44CF-9813-220DD9812298
wd:statement/Q5014566-21675932-12D8-4047-9586-7641EC9E1E90
wd:statement/Q5014566-2DEC53AC-BEE1-4873-984F-FCF1CB237A74
wd:statement/Q5014566-388E09F0-1976-4FBC-BF35-CA8A426F09DA
wd:statement/Q5014566-3F1B1367-93EF-4E6C-B434-D275CA6909D2
wd:statement/Q5014566-3FF93881-F0BA-4734-81D1-4110EC4D5A29
wd:statement/Q5014566-435FB259-EDB8-43FB-B4E3-7B4166E0D0A0
wd:statement/Q5014566-49431F04-097E-4FD0-ADCD-E59CF72400FB
wd:statement/Q5014566-63212BED-6FEA-4267-99CF-BBEC48DBDDCE
wd:statement/Q5014566-6567E798-7699-41D4-AA75-825614D5BFC1
wd:statement/Q5014566-659DE5CD-CD09-4B08-9B0C-E81F83BEBDA8
wd:statement/Q5014566-70C38844-0398-4797-9FC6-C677EC0DB24E
wd:statement/Q5014566-71C1E1A0-1F2A-4428-8E9F-C5AF3E70FAD1
wd:statement/Q5014566-7471C9D1-0274-4403-B56C-F9B9CDC0696A
wd:statement/Q5014566-75F613E4-3A2F-48BB-A750-20D884D848C4
wd:statement/Q5014566-769D8662-AD83-4770-9D90-40BF7B1D8FFC
wd:statement/Q5014566-78E7EDC6-B627-4D63-BFF1-B7B49189ED0E
wd:statement/Q5014566-7CE4A1CB-AD3E-462D-9BBA-ED9CC7A43F3A
wd:statement/Q5014566-88DA794F-CD4A-4DA6-87C6-F38715F255C9
wd:statement/Q5014566-8A21B8EF-DABC-4190-B093-12DBB6967754
wd:statement/Q5014566-8B4B29BA-2B66-4629-982D-91996EB7244D
wd:statement/Q5014566-90216800-3EDE-47A6-A6E3-E23024EA4F1E
wd:statement/Q5014566-911280EC-56A8-4FD1-B19C-9DEFB2D8320B
wd:statement/Q5014566-92F5FB77-3B2F-46A0-9CFD-27766AB8021B
wd:statement/Q5014566-9319F523-B91B-4AF1-B562-1FF37B32935E
wd:statement/Q5014566-9357A609-80F5-40D1-AE99-70F13BBBE931
wd:statement/Q5014566-9E10B06B-1E81-4C59-BA88-50F86E82FE45
wd:statement/Q5014566-A0E33044-8AB7-4222-A219-09174F1A7038
wd:statement/Q5014566-AACCD394-4A73-4D9A-A8D6-D1CDB27C9168
wd:statement/Q5014566-AD4C17D9-6031-49BC-AD76-78669C352206
wd:statement/Q5014566-B19E9846-0467-4AED-AE2A-CDBF836A36AA
wd:statement/Q5014566-B2218CD1-AE1A-43A1-B739-18152C60987A
wd:statement/Q5014566-BB1CC2FA-915E-45FD-BD0E-A85A54651021
wd:statement/Q5014566-BC9F669F-D525-4F47-AC19-8AC582651970
wd:statement/Q5014566-C36188AA-E3C7-4D21-A6C9-AA45C883DF4D
wd:statement/Q5014566-CB782523-E6D5-45D6-A627-21B2807F2102
wd:statement/Q5014566-D11517A9-0F09-4D60-9F7E-2BA0BCC7CDA3
wd:statement/Q5014566-D18346B5-1AEF-4EED-BD4D-F1D9FFDAE87B
wd:statement/Q5014566-D391A790-1F9D-40DB-A1CB-3008AFB2FB80
wd:statement/Q5014566-D67340C4-6C43-4B8C-AD0D-6DB82AB78333
wd:statement/Q5014566-D87E0429-F692-42B6-A3B6-515FA60CDCE4
wd:statement/Q5014566-E03F0200-D93E-400F-8943-B98EFE6A29B3
wd:statement/Q5014566-E5ED454C-9931-47C4-B9A9-E0EE5D75C887
wd:statement/Q5014566-EAC63FAF-E5FC-4069-98C1-4850C988B644
wd:statement/Q5014566-EE01EA1E-B228-43A1-8C93-53CBD31F4579
wd:statement/Q5014566-F87EF3BC-7C2F-4C92-82AC-FA530DB6B608
wd:statement/Q5014566-FD11B9BD-20BA-4628-9A74-9202C7A47813
wd:statement/Q5014566-FE319DA0-E5C6-4175-A6CA-3040F5A4846A
p:P692 wd:statement/Q5014566-71AE46D6-EC50-42AE-AA99-39C2D3FFF895
p:P702 wd:statement/Q5014566-D8A43D1C-35C4-4D06-9392-D663AA936EC6
p:P703 wd:statement/Q5014566-B387D8F4-4767-4D48-8CA4-F1F7B33E5CB2
p:P705 wd:statement/Q5014566-D5BC0910-3788-424F-93A5-8818207593F3
p:direct-normalized/P352 <http://purl.uniprot.org/uniprot/P29279>
p:direct-normalized/P486 <http://id.nlm.nih.gov/mesh/D055513>
p:direct-normalized/P637 <http://purl.uniprot.org/refseq/NP_001892>
p:direct-normalized/P672 <http://id.nlm.nih.gov/mesh/D12.644.276.200.100>
<http://id.nlm.nih.gov/mesh/D12.776.467.200.100>
<http://id.nlm.nih.gov/mesh/D12.776.860.300.200.100>
<http://id.nlm.nih.gov/mesh/D23.529.237.100>
wdt:P2888 <http://purl.uniprot.org/uniprot/P29279>
wdt:P2892 "C0110610"
wdt:P31 protein
wdt:P352 "P29279"
wdt:P361 Growth factor receptor cysteine-rich domain superfamily
IGFBP-related, CNN
Thrombospondin type-1 (TSP1) repeat superfamily
VWFC domain, protein family
Cystine knot, C-terminal domain, protein family
Glycoprotein hormone subunit beta, protein family
Insulin-like growth factor-binding protein, IGFBP family
Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site, protein family
Thrombospondin type-1 (TSP1) repeat, protein family
wdt:P486 "D055513"
wdt:P527 VWFC domain
Cystine knot, C-terminal
Thrombospondin type-1 (TSP1) repeat
Glycoprotein hormone subunit beta
Insulin-like growth factor-binding protein, IGFBP
Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
wdt:P637 "NP_001892"
wdt:P672 "D12.644.276.200.100"
"D12.776.467.200.100"
"D12.776.860.300.200.100"
"D23.529.237.100"
wdt:P680 integrin binding
protein C-terminus binding
heparin binding
growth factor activity
insulin-like growth factor binding
fibronectin binding
protein binding
wdt:P681 extracellular space
perinuclear region of cytoplasm
extracellular region
cis-Golgi network
extracellular matrix
cytosol
plasma membrane
cell cortex
collagen-containing extracellular matrix
wdt:P682 ossification
lung development
positive regulation of cell population proliferation
positive regulation of gene expression
response to estradiol
cell-cell signaling
positive regulation of cell differentiation
response to wounding
cell-matrix adhesion
positive regulation of protein phosphorylation
negative regulation of gene expression
positive regulation of cell death
negative regulation of cell death
response to peptide hormone
response to organic cyclic compound
positive regulation of collagen biosynthetic process
positive regulation of ERK1 and ERK2 cascade
intracellular signal transduction
regulation of cell growth
transcription initiation from RNA polymerase II promoter
response to amino acid
epidermis development
reactive oxygen species metabolic process
response to glucose
fibroblast growth factor receptor signaling pathway
positive regulation of JNK cascade
positive regulation of stress fiber assembly
regulation of signaling receptor activity
tissue homeostasis
integrin-mediated signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
cartilage condensation
response to fatty acid
regulation of chondrocyte differentiation
response to anoxia
chondrocyte proliferation
positive regulation of cell activation
response to mineralocorticoid
positive regulation of cardiac muscle contraction
extracellular matrix constituent secretion
positive regulation of G0 to G1 transition
cell adhesion
cell migration
cell differentiation
DNA biosynthetic process
connective tissue development
ageing
angiogenesis
wdt:P692 <http://commons.wikimedia.org/wiki/Special:FilePath/PBB%20GE%20CTGF%20209101%20at%20fs.png>
wdt:P702 CCN2
wdt:P703 human beings
wdt:P705 "ENSP00000356954"
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