SHMARQL

Janus kinase 3

<http://www.wikidata.org/entity/Q6155969>

mammalian protein found in Homo sapiens
Janus kinase 3
rdfs:label
"Janus kinase 3"@en
skos:altLabel
"JAK-3"@en
"JAK3"@en
"Janus kinase 3 (a protein tyrosine kinase, leukocyte)"@en
"L-JAK"@en
"leukocyte Janus kinase"@en
"tyrosine-protein kinase JAK3"@en
schema:description
"mammalian protein found in Homo sapiens"@en
schema:dateModified "2026-07-23T15:36:00+00:00"^^xsd:dateTime
schema:version 2521706483
wikibase:identifiers 30
wikibase:sitelinks 6
wikibase:statements 123
p:P10283 wd:statement/Q6155969-84F9323C-CF6B-4224-9D92-7032EFA6F393
p:P129 wd:statement/Q6155969-09F40D5D-212E-40AB-A0CC-D72083299578
wd:statement/Q6155969-3C49C95C-578A-44ED-87BC-A95BDC8AF031
wd:statement/Q6155969-3CF4F3C3-6D10-42B6-BE96-2359F4C6D4B0
wd:statement/Q6155969-49EFE5C6-AAE4-48D1-A743-95577E76D0B5
wd:statement/Q6155969-7B8643CD-FCF6-487F-AFCC-E2320FCE0379
wd:statement/Q6155969-B8185D9A-7991-4D4A-A943-31791E604AE8
wd:statement/Q6155969-D3044A6C-E2AA-4D0E-8A7B-B8D210D2AD3A
p:P18 wd:statement/Q6155969-30851062-AAF5-42FF-AB98-6CB6A629524C
p:P2892 wd:statement/Q6155969-5A2989D0-D397-466B-96B7-A55472B4247E
p:P31 wd:statement/Q6155969-3D0BC64C-37EC-4988-9598-EA8D93C46163
p:P352 wd:statement/Q6155969-C0A62D3D-09C0-4573-8B70-B36746B191D1
p:P361 wd:statement/Q6155969-0C32A109-30C7-4C60-9F32-79188CDB465E
wd:statement/Q6155969-365DF712-7255-4594-8A25-0266D7C6780C
wd:statement/Q6155969-44FD1005-126B-4A33-838D-B30648165673
wd:statement/Q6155969-4B53A277-828F-468E-B2F8-3BD32ACA69B0
wd:statement/Q6155969-56CD0E4B-EF60-46BF-8ED7-284D4FDC73DA
wd:statement/Q6155969-596244F7-91EC-4DC1-8354-FD7B53666526
wd:statement/Q6155969-629CEDF6-C13C-487D-97ED-7E5899A3C2B6
wd:statement/Q6155969-B995AB9B-5C68-4E56-8AA3-357B7956BFEA
wd:statement/Q6155969-E0E2924C-735B-4CE7-9924-55C25832E845
wd:statement/Q6155969-E6B0BD2F-9104-4819-87DA-5FED6B2A9491
wd:statement/Q6155969-F13BC2CE-40F7-4168-8751-451962C2FE26
p:P486 wd:statement/Q6155969-20f48abe-40c6-d797-e6f8-c2d0859686b8
p:P527 wd:statement/Q6155969-2529B5DD-CF65-4AA0-9E05-052DD67B278A
wd:statement/Q6155969-2662B16D-6E49-4A5B-BF16-24A724025CD8
wd:statement/Q6155969-45314C27-44B0-4FC3-BB63-A8F311B4C0DB
wd:statement/Q6155969-523578F3-9933-47B2-8D52-0180C11BBF70
wd:statement/Q6155969-9BFB674A-28E0-4460-9994-A74DC567DE21
wd:statement/Q6155969-AADC5F13-8339-45FD-A761-A1D25C4D1708
wd:statement/Q6155969-EEF9E6BF-A6F0-44E0-8D32-DA2EBE71862F
wd:statement/Q6155969-F4837769-030C-4486-BF0E-165D5CCEB300
p:P591 wd:statement/Q6155969-19086171-7F09-474E-84BA-2AD4A6BC93C7
p:P637 wd:statement/Q6155969-12B5D2FB-E0DB-44CA-8FC4-9787E5A82FEF
wd:statement/Q6155969-C57A6784-0487-4EA0-ACF0-E9B737900421
wd:statement/Q6155969-D074AC20-34F0-4899-834F-70A29A86AA73
p:P638 wd:statement/Q6155969-04F8D9C3-EAA1-4DA7-80B1-A0E87B365990
wd:statement/Q6155969-0D90DBD8-C98B-470D-85EC-EE0E10F22408
wd:statement/Q6155969-42C2E55C-27D2-434D-912A-887EADD37BC0
wd:statement/Q6155969-4BB92AB3-55D7-4DB3-97B2-59AEB28E301E
wd:statement/Q6155969-6E4D830F-9063-4A6B-88A4-CB8A900842B6
wd:statement/Q6155969-6F89D5B6-5513-4597-88BF-29D3AA5371FA
wd:statement/Q6155969-82C3BDE9-7CAE-4D91-9A44-5B1DB402BA53
wd:statement/Q6155969-86E53696-0045-4627-A4CF-F027B546E250
wd:statement/Q6155969-8A609ECE-D19C-4442-BA4E-623E171F51D6
wd:statement/Q6155969-8B40D3BA-899C-4FF2-B85E-DDBE966B586B
wd:statement/Q6155969-95BD2129-DDCE-4D94-AEF0-3EA153FB9A88
wd:statement/Q6155969-96371CCC-96E2-4967-AA48-B984C8917D83
wd:statement/Q6155969-99CE6FB8-D883-4D61-BC41-35ADFA5E1706
wd:statement/Q6155969-A0E20951-BB90-40BE-A484-3D16382725FE
wd:statement/Q6155969-D264D074-A788-448A-AA44-0E1E1EEAF880
wd:statement/Q6155969-E59B5C82-7866-46D4-927A-14ACD7481C9D
p:P646 wd:statement/Q6155969-9D6855A9-E6D0-4D1B-A7E3-B6F36C3DDCDB
p:P672 wd:statement/Q6155969-c96de520-4064-b416-1b04-cc42d556cbc3
wd:statement/Q6155969-fba50b8e-4981-b5b8-de65-c74284c73ad2
p:P680 wd:statement/Q6155969-3B9350FF-476C-49A0-B5E6-C8E3F5A0D37A
wd:statement/Q6155969-42C9D32D-2ED8-4378-9A42-7ECC83413FFE
wd:statement/Q6155969-5F14D29F-8DA8-4188-9ED8-CD964DDDE0A1
wd:statement/Q6155969-6AFED907-AC94-41BB-83C5-755C7B70893F
wd:statement/Q6155969-75C9E81F-E510-42A5-A94E-C69B5BB3DDDE
wd:statement/Q6155969-8FFAC95C-96FF-413E-B9A8-4105439544E4
wd:statement/Q6155969-909B5F0C-DE89-4CF4-89AD-9077904694B9
wd:statement/Q6155969-D36F5201-8838-4D75-B397-607C6D66E3D3
wd:statement/Q6155969-D398F433-46BD-423A-A42E-DDABF816D748
wd:statement/Q6155969-EFC95E16-1C71-4487-8E2F-90160049A0FB
wd:statement/Q6155969-EFD1A05F-902C-4744-B188-2CC9DA4324D1
p:P681 wd:statement/Q6155969-3120CB03-F35A-4DC4-A448-CA83AA3F4CAF
wd:statement/Q6155969-36505A99-778C-45EC-ADA7-CB8AC07C9B1E
wd:statement/Q6155969-55CB8844-F6AD-4079-870B-4BEBCED935DB
wd:statement/Q6155969-8D72E7F9-476C-42EA-B7BE-8B4940A80411
wd:statement/Q6155969-AAE45222-E080-4417-9AE1-9BFBAA4FB1A8
wd:statement/Q6155969-B9573C32-1190-47EF-8DB6-9DA745BBEBE0
wd:statement/Q6155969-CFDCC487-4111-4108-BBDE-2DFB04BAF669
wd:statement/Q6155969-EE2B25C3-2BF7-443F-9C71-3AA3721D3911
p:P682 wd:statement/Q6155969-0439A419-736E-4FF9-A118-FEACAFD3C10F
wd:statement/Q6155969-066D59B1-2976-404F-ACA1-3FBC10CA6F03
wd:statement/Q6155969-0BC32FF7-B436-4C45-926B-46ED273FB02E
wd:statement/Q6155969-10AAA15E-BC01-451B-A876-CEDF766F371E
wd:statement/Q6155969-1951393F-711C-4B70-95F2-7E96D2019EF1
wd:statement/Q6155969-21DFEF60-622D-426D-9483-52B85AE23173
wd:statement/Q6155969-2C3C12D6-6C6B-40E9-BACD-F0A52BD2F30E
wd:statement/Q6155969-317CC7A3-E817-4EA1-9A8E-9DDEF833B342
wd:statement/Q6155969-327DB928-4EBA-41CE-AA05-3AA56D12E3DB
wd:statement/Q6155969-34265D25-46F4-48F9-B91A-4AC6B4EC9205
wd:statement/Q6155969-3F49B188-1A71-4DE3-8A27-F6972A939B16
wd:statement/Q6155969-4F7F1EFE-50C3-46D1-93A8-9B206FAFBB08
wd:statement/Q6155969-55A077BF-E600-4482-B1E9-298794C13A65
wd:statement/Q6155969-57800FB6-1C8B-49B3-8D09-8DEC795CF641
wd:statement/Q6155969-6045C555-F985-4976-89B1-12E1EB265D7A
wd:statement/Q6155969-6454C50C-7343-4F10-9042-C61E41CE1BBA
wd:statement/Q6155969-6E197BD3-7BD0-4994-B312-5F401C8CAF07
wd:statement/Q6155969-78B0DA47-1751-463F-ABDD-7A4F815A53D0
wd:statement/Q6155969-8875532B-A51D-47E9-A9A5-66319BAD746A
wd:statement/Q6155969-8AB0892B-E993-4C4B-BE98-B79F2ADDE56F
wd:statement/Q6155969-91B452DD-465B-484C-97AA-EB1E902F5F46
wd:statement/Q6155969-93B6DF9B-E14F-4002-93C4-A889AA64D98D
wd:statement/Q6155969-9614E5D7-5187-420F-BD61-3145C7FEBC01
wd:statement/Q6155969-9C96DC10-D248-4BC6-9E5A-CB26B6882F49
wd:statement/Q6155969-A25947B0-66BA-4CF3-901B-CEE2E31A3674
wd:statement/Q6155969-A2EB2FF2-7384-40B4-88B9-FA788F8F7C05
wd:statement/Q6155969-A771FE9B-05C3-4DE3-9182-283C63CC9650
wd:statement/Q6155969-B027B86F-C012-4D5E-B1CA-4BF0E66AB7FC
wd:statement/Q6155969-B38F5EA3-7038-45B1-89D2-FB8CE5FFD3E5
wd:statement/Q6155969-B7FA8189-A586-455A-8F53-F3FD9A23598E
wd:statement/Q6155969-BA0233DE-8365-4C28-A15F-C7E97F977E14
wd:statement/Q6155969-BEC4F6FD-5AD3-4062-82C7-EBB5E59FC9B1
wd:statement/Q6155969-C284B2D7-42BC-4732-9A52-E6C8017EE471
wd:statement/Q6155969-CA25BCB3-CD80-4CEF-BD55-4164033423BD
wd:statement/Q6155969-CDBA852B-57FB-46ED-938E-B45FE0C5F9E2
wd:statement/Q6155969-D8E7C35E-EC29-4F48-B21D-56936AB73D18
wd:statement/Q6155969-D93321BF-B2C6-4C5C-A016-1A702F4D7B04
wd:statement/Q6155969-DA003AAF-1B9C-4BB5-8D51-CCAD301B5017
wd:statement/Q6155969-E159FFB7-3B0D-4844-A60F-64F326279681
wd:statement/Q6155969-E72DB1A6-E404-42B6-ACE4-CB2126205ED5
wd:statement/Q6155969-EE510E8C-AF71-4E36-A180-1D390D447B31
wd:statement/Q6155969-F2AAEB37-44C5-40EB-B326-5B42F382B357
wd:statement/Q6155969-F9362355-E74A-45D3-8AAD-DC37ADFF5080
p:P702 wd:statement/Q6155969-EC074CB0-40FF-4E2C-B856-6C46F66F31E8
p:P703 wd:statement/Q6155969-DF03D618-465E-4007-A605-7FD0563874C2
p:P705 wd:statement/Q6155969-1722DB0E-E30A-40B7-A514-482B2D085C16
wd:statement/Q6155969-7D9B2BF7-E2F7-4792-9BB4-AEA82C2F59EB
wd:statement/Q6155969-C9649019-5955-4E80-BE38-A306A8423BC8
p:P8636 wd:statement/Q6155969-66CEFB97-A9AC-49D0-B0B2-F889886E9C96
p:direct-normalized/P352 <http://purl.uniprot.org/uniprot/P52333>
p:direct-normalized/P486 <http://id.nlm.nih.gov/mesh/D053616>
p:direct-normalized/P637 <http://purl.uniprot.org/refseq/NP_000206>
<http://purl.uniprot.org/refseq/XP_011526292>
<http://purl.uniprot.org/refseq/XP_011526293>
p:direct-normalized/P638 <https://rdf.wwpdb.org/pdb/1YVJ>
<https://rdf.wwpdb.org/pdb/3LXK>
<https://rdf.wwpdb.org/pdb/3LXL>
<https://rdf.wwpdb.org/pdb/3PJC>
<https://rdf.wwpdb.org/pdb/3ZC6>
<https://rdf.wwpdb.org/pdb/3ZEP>
<https://rdf.wwpdb.org/pdb/4HVD>
<https://rdf.wwpdb.org/pdb/4HVG>
<https://rdf.wwpdb.org/pdb/4HVH>
<https://rdf.wwpdb.org/pdb/4HVI>
<https://rdf.wwpdb.org/pdb/4I6Q>
<https://rdf.wwpdb.org/pdb/4QPS>
<https://rdf.wwpdb.org/pdb/4QT1>
<https://rdf.wwpdb.org/pdb/4RIO>
<https://rdf.wwpdb.org/pdb/4V0G>
<https://rdf.wwpdb.org/pdb/4Z16>
p:direct-normalized/P672 <http://id.nlm.nih.gov/mesh/D08.811.913.696.620.682.725.124.300>
<http://id.nlm.nih.gov/mesh/D12.776.476.568.124.300>
wdt:P10283 "C183315844"
wdt:P129 momelotinib
upadacitinib
decernotinib
peficitinib
tofacitinib
pacritinib
ruxolitinib
wdt:P18 <http://commons.wikimedia.org/wiki/Special:FilePath/Protein%20JAK3%20PDB%201yvj.png>
wdt:P2892 "C0253457"
wdt:P31 protein
wdt:P352 "P52333"
wdt:P361 Protein kinase-like domain superfamily
tyrosine-protein kinase, non-receptor Jak3
SH2 domain superfamily
Tyrosine-protein kinase, catalytic domain, protein family
FERM domain, protein family
Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
Protein kinase domain, protein family
SH2 domain, protein family
Band 4.1 domain, protein family
Tyrosine-protein kinase, active site, protein family
Protein kinase, ATP binding site, protein family
wdt:P486 "D053616"
wdt:P527 tyrosine-protein kinase, catalytic domain
FERM domain
tyrosine-protein kinase, active site
serine-threonine/tyrosine-protein kinase, catalytic domain
protein kinase domain
protein kinase, ATP binding site
SH2 domain
Band 4.1 domain
wdt:P591 "2.7.10.2"
wdt:P637 "NP_000206"
"XP_011526292"
"XP_011526293"
wdt:P638 "1YVJ"
"3LXK"
"3LXL"
"3PJC"
"3ZC6"
"3ZEP"
"4HVD"
"4HVG"
"4HVH"
"4HVI"
"4I6Q"
"4QPS"
"4QT1"
"4RIO"
"4V0G"
"4Z16"
wdt:P646 "/m/02rvjj6"
wdt:P672 "D08.811.913.696.620.682.725.124.300"
"D12.776.476.568.124.300"
wdt:P680 ATP binding
signaling receptor binding
protein kinase activity
transferase activity
nucleotide binding
protein phosphatase binding
kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
wdt:P681 membrane
extrinsic component of cytoplasmic side of plasma membrane
cytoskeleton
cytosol
plasma membrane
cytoplasm
endosome
endomembrane system
wdt:P682 peptidyl-tyrosine phosphorylation
regulation of apoptotic process
MAPK cascade
inflammatory response
growth hormone receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via JAK-STAT
tyrosine phosphorylation of STAT protein
intracellular signal transduction
erythrocyte differentiation
cytokine-mediated signaling pathway
T cell homeostasis
B cell differentiation
negative regulation of interleukin-12 production
positive regulation of T cell proliferation
negative regulation of thymocyte apoptotic process
enzyme linked receptor protein signaling pathway
negative regulation of interleukin-10 production
negative regulation of T cell activation
interleukin-4-mediated signaling pathway
interleukin-2-mediated signaling pathway
interleukin-7-mediated signaling pathway
adaptive immune response
response to interleukin-4
negative regulation of dendritic cell cytokine production
negative regulation of FasL production
negative regulation of T-helper 1 cell differentiation
regulation of T cell apoptotic process
response to interleukin-2
response to interleukin-15
response to interleukin-9
immune system process
peptidyl-tyrosine autophosphorylation
cell migration
interleukin-15-mediated signaling pathway
interleukin-21-mediated signaling pathway
interleukin-9-mediated signaling pathway
phosphorylation
innate immune response
protein phosphorylation
wdt:P702 JAK3
wdt:P703 man
wdt:P705 "ENSP00000391676"
"ENSP00000432511"
"ENSP00000436421"
wdt:P8636 "J/janus-(3)"
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data from SPARQL profile: Wikidata